PLTP

Phospholipid transfer protein
Identifiers
Symbols	PLTP ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4536
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PLTP 202075 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Phospholipid transfer protein, also known as PLTP, is a human gene.

The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Jiang XC (2002). "The effect of phospholipid transfer protein on lipoprotein metabolism and atherosclerosis". Front. Biosci. 7: d1634–41. PMID 12086920.
• Albers JJ, Cheung MC (2005). "Emerging roles for phospholipid transfer protein in lipid and lipoprotein metabolism". Curr. Opin. Lipidol. 15 (3): 255–60. PMID 15166780.
• Dallinga-Thie GM, Dullaart RP, van Tol A (2007). "Concerted actions of cholesteryl ester transfer protein and phospholipid transfer protein in type 2 diabetes: effects of apolipoproteins". Curr. Opin. Lipidol. 18 (3): 251–7. doi:10.1097/MOL.0b013e3280e12685. PMID 17495597.CS1 maint: Multiple names: authors list (link)
• Whitmore TE, Day JR, Albers JJ (1996). "Localization of the human phospholipid transfer protein gene to chromosome 20q12-q13.1". Genomics. 28 (3): 599–600. doi:10.1006/geno.1995.1198. PMID 7490104.CS1 maint: Multiple names: authors list (link)
• Albers JJ, Wolfbauer G, Cheung MC; et al. (1995). "Functional expression of human and mouse plasma phospholipid transfer protein: effect of recombinant and plasma PLTP on HDL subspecies". Biochim. Biophys. Acta. 1258 (1): 27–34. PMID 7654777.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Day JR, Albers JJ, Lofton-Day CE; et al. (1994). "Complete cDNA encoding human phospholipid transfer protein from human endothelial cells". J. Biol. Chem. 269 (12): 9388–91. PMID 8132678.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tu AY, Wolfbauer G, Albers JJ (1996). "Functional characterization of the promoter region of the human phospholipid transfer protein gene". Biochem. Biophys. Res. Commun. 217 (3): 705–11. doi:10.1006/bbrc.1995.2830. PMID 8554588.CS1 maint: Multiple names: authors list (link)
• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hailman E, Albers JJ, Wolfbauer G; et al. (1996). "Neutralization and transfer of lipopolysaccharide by phospholipid transfer protein". J. Biol. Chem. 271 (21): 12172–8. PMID 8647810.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pussinen PJ, Jauhiainen M, Metso J; et al. (1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". J. Lipid Res. 39 (1): 152–61. PMID 9469594.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jiang XC, D'Armiento J, Mallampalli RK; et al. (1998). "Expression of plasma phospholipid transfer protein mRNA in normal and emphysematous lungs and regulation by hypoxia". J. Biol. Chem. 273 (25): 15714–8. PMID 9624168.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jauhiainen M, Huuskonen J, Baumann M; et al. (1999). "Phospholipid transfer protein (PLTP) causes proteolytic cleavage of apolipoprotein A-I". J. Lipid Res. 40 (4): 654–64. PMID 10191289.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Qu SJ, Fan HZ, Kilinc C, Pownall HJ (1999). "Role of cysteine residues in human plasma phospholipid transfer protein". J. Protein Chem. 18 (2): 193–8. PMID 10333293.CS1 maint: Multiple names: authors list (link)
• Lie J, de Crom R, Jauhiainen M; et al. (2002). "Evaluation of phospholipid transfer protein and cholesteryl ester transfer protein as contributors to the generation of pre beta-high-density lipoproteins". Biochem. J. 360 (Pt 2): 379–85. PMID 11716766.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kärkkäinen M, Oka T, Olkkonen VM; et al. (2002). "Isolation and partial characterization of the inactive and active forms of human plasma phospholipid transfer protein (PLTP)". J. Biol. Chem. 277 (18): 15413–8. doi:10.1074/jbc.M112247200. PMID 11854286.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Murdoch SJ, Wolfbauer G, Kennedy H; et al. (2002). "Differences in reactivity of antibodies to active versus inactive PLTP significantly impacts PLTP measurement". J. Lipid Res. 43 (2): 281–9. PMID 11861670.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)