POLA1

Polymerase (DNA directed), alpha 1
File:PBB Protein POLA1 image.jpg PDB rendering based on 1k0p.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1k0p​, 1k18​, 1n5g​
Identifiers
Symbols	POLA1 ; DKFZp686K1672; POLA
External IDs	Template:OMIM5 Template:MGI HomoloGene: 6802
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE POLA1 204835 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Polymerase (DNA directed), alpha 1, also known as POLA1, is a human gene.

Further reading

• Pollok S, Stoepel J, Bauerschmidt C; et al. (2003). "Regulation of eukaryotic DNA replication at the initiation step". Biochem. Soc. Trans. 31 (Pt 1): 266–9. doi:10.1042/ . PMID 12546699.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fisher PA, Korn D (1977). "DNA polymerase-alpha. Purification and structural characterization of the near homogeneous enzyme from human KB cells". J. Biol. Chem. 252 (18): 6528–35. PMID 893425.
• Dornreiter I, Erdile LF, Gilbert IU; et al. (1992). "Interaction of DNA polymerase alpha-primase with cellular replication protein A and SV40 T antigen". EMBO J. 11 (2): 769–76. PMID 1311258.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Coverley D, Kenny MK, Lane DP, Wood RD (1992). "A role for the human single-stranded DNA binding protein HSSB/RPA in an early stage of nucleotide excision repair". Nucleic Acids Res. 20 (15): 3873–80. PMID 1508673.CS1 maint: Multiple names: authors list (link)
• Popanda O, Thielmann HW (1992). "The function of DNA polymerases in DNA repair synthesis of ultraviolet-irradiated human fibroblasts". Biochim. Biophys. Acta. 1129 (2): 155–60. PMID 1730053.
• Collins KL, Kelly TJ (1991). "Effects of T antigen and replication protein A on the initiation of DNA synthesis by DNA polymerase alpha-primase". Mol. Cell. Biol. 11 (4): 2108–15. PMID 1848671.
• Martelli AM, Cocco L, Manzoli FA (1991). "On the association of DNA polymerase alpha activity with the nuclear matrix in HeLa cells". Cell Biol. Int. Rep. 15 (2): 131–40. PMID 1903085.CS1 maint: Multiple names: authors list (link)
• Pearson BE, Nasheuer HP, Wang TS (1991). "Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells". Mol. Cell. Biol. 11 (4): 2081–95. PMID 2005899.CS1 maint: Multiple names: authors list (link)
• Matsumoto T, Eki T, Hurwitz J (1991). "Studies on the initiation and elongation reactions in the simian virus 40 DNA replication system". Proc. Natl. Acad. Sci. U.S.A. 87 (24): 9712–6. PMID 2175912.CS1 maint: Multiple names: authors list (link)
• Hsi KL, Copeland WC, Wang TS (1991). "Human DNA polymerase alpha catalytic polypeptide binds ConA and RCA and contains a specific labile site in the N-terminus". Nucleic Acids Res. 18 (21): 6231–7. PMID 2243771.CS1 maint: Multiple names: authors list (link)
• Wang TS, Pearson BE, Suomalainen HA; et al. (1985). "Assignment of the gene for human DNA polymerase alpha to the X chromosome". Proc. Natl. Acad. Sci. U.S.A. 82 (16): 5270–4. PMID 2410918.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Knorre DG, Lavrik OI, Nevinsky GA (1988). "Protein-nucleic acid interaction in reactions catalyzed with DNA polymerases". Biochimie. 70 (5): 655–61. PMID 3139084.CS1 maint: Multiple names: authors list (link)
• Nishida C, Reinhard P, Linn S (1988). "DNA repair synthesis in human fibroblasts requires DNA polymerase delta". J. Biol. Chem. 263 (1): 501–10. PMID 3335506.CS1 maint: Multiple names: authors list (link)
• Wong SW, Wahl AF, Yuan PM; et al. (1988). "Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases". EMBO J. 7 (1): 37–47. PMID 3359994.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsuda M, Masuyama M, Katsunuma T (1986). "Inhibition of human DNA polymerase alpha by alpha 1-antichymotrypsin". Cancer Res. 46 (12 Pt 1): 6139–42. PMID 3490907.CS1 maint: Multiple names: authors list (link)
• Jackson DA, Cook PR (1987). "Different populations of DNA polymerase alpha in HeLa cells". J. Mol. Biol. 192 (1): 77–86. PMID 3820307.
• Miller MR, Seighman C, Ulrich RG (1986). "Inhibition of DNA replication and DNA polymerase alpha activity by monoclonal anti-(DNA polymerase alpha) immunoglobulin G and F(ab) fragments". Biochemistry. 24 (25): 7440–5. PMID 4084590.CS1 maint: Multiple names: authors list (link)
• Bensch KG, Tanaka S, Hu SZ; et al. (1982). "Intracellular localization of human DNA polymerase alpha with monoclonal antibodies". J. Biol. Chem. 257 (14): 8391–6. PMID 7045121.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanaka S, Hu SZ, Wang TS, Korn D (1982). "Preparation and preliminary characterization of monoclonal antibodies against human DNA polymerase alpha". J. Biol. Chem. 257 (14): 8386–90. PMID 7085672.CS1 maint: Multiple names: authors list (link)
• Eckert KA, Kunkel TA (1994). "Fidelity of DNA synthesis catalyzed by human DNA polymerase alpha and HIV-1 reverse transcriptase: effect of reaction pH". Nucleic Acids Res. 21 (22): 5212–20. PMID 7504813.