PREP (gene)

Prolyl endopeptidase
File:PBB Protein PREP image.jpg PDB rendering based on 1e5t.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1e5t​, 1e8m​, 1e8n​, 1h2w​, 1h2x​, 1h2y​, 1h2z​, 1o6f​, 1o6g​, 1qfm​, 1qfs​, 1uoo​, 1uop​, 1uoq​, 1vz2​, 1vz3​
Identifiers
Symbols	PREP ; PEP; MGC16060; PE
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2042
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE PREP 37950 at tn.png
File:PBB GE PREP 204117 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Prolyl endopeptidase, also known as PREP, is a human gene.

The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides.

Further reading

• Mentlein R (1988). "Proline residues in the maturation and degradation of peptide hormones and neuropeptides". FEBS Lett. 234 (2): 251–6. PMID 3292288.
• Wilk S (1984). "Prolyl endopeptidase". Life Sci. 33 (22): 2149–57. PMID 6358755.
• Koida M, Walter R (1977). "Post-proline cleaving enzyme. Purification of this endopeptidase by affinity chromatography". J. Biol. Chem. 251 (23): 7593–9. PMID 12173.
• Swanson AA, Davis RM, Meinhardt NC (1985). "Proteases in human lenses and their possible significance". Curr. Eye Res. 4 (1): 43–8. PMID 2858361.CS1 maint: Multiple names: authors list (link)
• Momand J, Clarke S (1988). "Rapid degradation of D- and L-succinimide-containing peptides by a post-proline endopeptidase from human erythrocytes". Biochemistry. 26 (24): 7798–805. PMID 3480758.
• Checler F, Vincent JP, Kitabgi P (1986). "Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes". J. Biol. Chem. 261 (24): 11274–81. PMID 3525564.CS1 maint: Multiple names: authors list (link)
• Daly DJ, Maskrey P, Pennington RJ (1985). "Characterization of proline endopeptidase from skeletal muscle". Int. J. Biochem. 17 (4): 521–4. PMID 3891453.CS1 maint: Multiple names: authors list (link)
• Sumi S, Mizutani S, Narita O, Tomoda Y (1985). "Purification and properties of a human placental post-proline endopeptidase". Nippon Sanka Fujinka Gakkai Zasshi. 36 (10): 1943–51. PMID 6389730.CS1 maint: Multiple names: authors list (link)
• Goossens F, De Meester I, Vanhoof G; et al. (1995). "The purification, characterization and analysis of primary and secondary-structure of prolyl oligopeptidase from human lymphocytes. Evidence that the enzyme belongs to the alpha/beta hydrolase fold family". Eur. J. Biochem. 233 (2): 432–41. PMID 7588785.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vanhoof G, Goossens F, Hendriks L; et al. (1994). "Cloning and sequence analysis of the gene encoding human lymphocyte prolyl endopeptidase". Gene. 149 (2): 363–6. PMID 7959018.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shirasawa Y, Osawa T, Hirashima A (1994). "Molecular cloning and characterization of prolyl endopeptidase from human T cells". J. Biochem. 115 (4): 724–9. PMID 8089089.CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Goossens FJ, Wauters JG, Vanhoof GC; et al. (1996). "Subregional mapping of the human lymphocyte prolyl oligopeptidase gene (PREP) to human chromosome 6q22". Cytogenet. Cell Genet. 74 (1–2): 99–101. PMID 8893811.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fülöp V, Böcskei Z, Polgár L (1998). "Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis". Cell. 94 (2): 161–70. PMID 9695945.CS1 maint: Multiple names: authors list (link)
• Quinto BM, Juliano MA, Hirata I; et al. (2001). "Characterization of a prolyl endopeptidase (kininase) from human urine using fluorogenic quenched substrates". Int. J. Biochem. Cell Biol. 32 (11–12): 1161–72. PMID 11137456.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Irazusta J, Larrinaga G, González-Maeso J; et al. (2002). "Distribution of prolyl endopeptidase activities in rat and human brain". Neurochem. Int. 40 (4): 337–45. PMID 11792464.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bellemère G, Morain P, Vaudry H, Jégou S (2003). "Effect of S 17092, a novel prolyl endopeptidase inhibitor, on substance P and alpha-melanocyte-stimulating hormone breakdown in the rat brain". J. Neurochem. 84 (5): 919–29. PMID 12603817.CS1 maint: Multiple names: authors list (link)