PRRC2A

The PRRCA gene codes for the proline-rich coiled coil 2A, also known as BAT2. The BAT cluster of genes is found near the genes for TNF alpha and beta. PRRCA can be found in the human major histocompatibility complex class III region, found on chromosome 6 in humans and chromosome 17 in mouse. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis.