Paget's disease of the breast epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Preeti Singh, M.B.B.S.[2]
Overview
Paget's disease of the breast occurs in 0.5–5% of all breast cancer cases and is invariably associated with underlying malignancy either overt or occult. WHO revealed that there are 800,000 up to 1 million new cases of breast cancer each year. An underlying breast carcinoma is found in >90% of patients with Paget's disease. The majority of these cases are invasive disease although 40 – 45% are associated with ductal carcinoma in situ. Paget's disease of the breast is more prevalent in postmenopausal women, usually after the sixth decade of life, but it has also been reported in adolescent and elderly patients. Females are more commonly affected with Paget's disease of the breast than males. Male breast cancer accounts for less than 1% of all breast cancer and Paget's disease represents 1-3% of all breast malignancies.
Epidemiology and Demographics
- Paget's disease of the breast occurs in 0.5–5% of all breast cancer cases and is invariably associated with underlying malignancy either overt or occult.
- WHO revealed that there are 800,000 up to 1 million new cases of breast cancer each year.[1]
- An underlying breast carcinoma is found in >90% of patients with Paget's disease.
- The majority of these cases are invasive disease although 40 – 45% are associated with ductal carcinoma in situ.[2]
Age
- Paget's disease of the breast is more prevalent in postmenopausal women, usually after the sixth decade of life, but it has also been reported in adolescent and elderly patients.
Gender
- Females are more commonly affected with Paget's disease of the breast than males.[3]
- Male breast cancer accounts for less than 1% of all breast cancer and Paget's disease represents 1-3% of all breast malignancies.[4]
References
- ↑ Delaloge, Suzette; Bachelot, Thomas; Bidard, François-Clément; Espie, Marc; Brain, Etienne; Bonnefoi, Hervé; Gligorov, Joseph; Dalenc, Florence; Hardy-Bessard, Anne-Claire; Azria, David; Jacquin, Jean-Philippe; Lemonnier, Jérôme; Jacot, William; Goncalves, Anthony; Coutant, Charles; Ganem, Gérard; Petit, Thierry; Penault-Lorca, Frédérique; Debled, Marc; Campone, Mario; Levy, Christelle; Coudert, Bruno; Lortholary, Alain; Venat-Bouvet, Laurence; Grenier, Julien; Bourgeois, Hugues; Asselain, Bernard; Arvis, Johanna; Castro, Martine; Tardivon, Anne; Cox, David G.; Arveux, Patrick; Balleyguier, Corinne; André, Fabrice; Rouzier, Roman (2016). "Dépistage du cancer du sein : en route vers le futur". Bulletin du Cancer. 103 (9): 753–763. doi:10.1016/j.bulcan.2016.06.005. ISSN 0007-4551.
- ↑ Subramanian, Ashok; Birch, Hilary; McAvinchey, Rita; Stacey-Clear, Adam (2007). "Pagets disease of uncertain origin: case report". International Seminars in Surgical Oncology. 4 (1): 12. doi:10.1186/1477-7800-4-12. ISSN 1477-7800.
- ↑ Dixon AR, Galea MH, Ellis IO, Elston CW, Blamey RW (June 1991). "Paget's disease of the nipple". Br J Surg. 78 (6): 722–3. PMID 1648987.
- ↑ Fouad, Dina (2011). "Paget's disease of the breast in a male with lymphomatoid papulosis: a case report". Journal of Medical Case Reports. 5 (1): 43. doi:10.1186/1752-1947-5-43. ISSN 1752-1947.