Paramethadione

Paramethadione

Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	US: D (Evidence of risk)
ATC code	N03AC01 (WHO)
Pharmacokinetic data
Protein binding	Not significant
Identifiers
IUPAC name (RS)-5-ethyl-3,5-dimethyl-oxazolidine-2,4-dione
CAS Number	115-67-3
PubChem CID	8280
DrugBank	DB00617 Y
ChemSpider	7979 Y
UNII	Z615FRW64N
KEGG	D00495 Y
ChEMBL	ChEMBL1100 Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C7H11NO3
Molar mass	157.167 g/mol
3D model (JSmol)	Interactive image
SMILES O=C1N(C(=O)OC1(C)CC)C
InChI InChI=1S/C7H11NO3/c1-4-7(2)5(9)8(3)6(10)11-7/h4H2,1-3H3 Y Key:VQASKUSHBVDKGU-UHFFFAOYSA-N Y
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Paramethadione is an anticonvulsant in the oxazolidinedione class. It is associated with fetal trimethadione syndrome, which is also known as paramethadione syndrome.

Chemistry

Paramethadione, 5-ethyl-3,5-dimethyloxazolidine-2,4-dione, differs from trimethadione only in the substitution of one methyl group with an ethyl group. It is synthesized in a completely analogous manner, except that it comes from 2-hydroxy-2-methylbutyric acid instead of 2-hydroxyisobutyric acid.

• M.A. Spielman, Template:US Patent (1951).

External links

• Template:DiseasesDB
• Hoffman, D; Chun A (1975). "Paramethadione and metabolite serum levels in humans after a single oral paramethadione dose". J Pharm Sci. 64 (10): 1702–1703. doi:10.1002/jps.2600641027. PMID 1185541.

Template:Anticonvulsants