Paroxysmal nocturnal hemoglobinuria history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

Common symptoms of paroxysmal nocturnal hemoglobinuria include fatigue, dyspnea, headaches, abdominal pain, dysphagia and chest pain. Less common symptoms may include necrotic skin lesions.

History and Symptoms

History

Patients with PNH may have a positive history of:

• Feeling tired/ weak
• Shortness of breath
• Dark colored urine
• Jaundice
• Blood clots
• Difficulty swallowing
• Chest pain
• Abdominal pain
• Headaches
• Confusion
• Dysphagia
• Erectile dysfunction
• Low blood cell counts
• Iron deficiency

Common Symptoms

Common symptoms of PNH include:

• Due to hemolysis
  1. Fatigue
  2. Dyspnea
  3. Jaundice

• Due to thrombosis:
  1. Headaches
  2. Confusion
  3. Abdominal pain
  4. Chest pain

• Due to nitric oxide depletion:
  1. Dysphagia
  2. Chest pain
  3. Abdominal pain
  4. Erectile dysfunction

Less Common Symptoms

Less common symptoms of PNH include:

• Necrotic skin lesions