Peptidase inhibitor 3

Peptidase inhibitor 3, skin-derived (SKALP)
File:PBB Protein PI3 image.jpg PDB rendering based on 1fle.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1fle​, 2rel​
Identifiers
Symbols	PI3 ; ESI; MGC13613; SKALP; WAP3; WFDC14
External IDs	Template:OMIM5 HomoloGene: 48118
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE PI3 41469 at tn.png
File:PBB GE PI3 203691 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Peptidase inhibitor 3, skin-derived (SKALP), also known as PI3, is a human gene.

This gene encodes an elastase-specific inhibitor, which contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.

Further reading

• Sallenave JM (2003). "The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease". Respir. Res. 1 (2): 87–92. PMID 11667971.
• Saheki T, Ito F, Hagiwara H; et al. (1992). "Primary structure of the human elafin precursor preproelafin deduced from the nucleotide sequence of its gene and the presence of unique repetitive sequences in the prosegment". Biochem. Biophys. Res. Commun. 185 (1): 240–5. PMID 1339270.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sallenave JM, Marsden MD, Ryle AP (1992). "Isolation of elafin and elastase-specific inhibitor (ESI) from bronchial secretions. Evidence of sequence homology and immunological cross-reactivity". Biol. Chem. Hoppe-Seyler. 373 (1): 27–33. PMID 1536690.CS1 maint: Multiple names: authors list (link)
• Chang A, Schalkwijk J, Happle R, van de Kerkhof PC (1990). "Elastase-inhibiting activity in scaling skin disorders". Acta Derm. Venereol. 70 (2): 147–51. PMID 1969201.CS1 maint: Multiple names: authors list (link)
• Schalkwijk J, de Roo C, de Jongh GJ (1991). "Skin-derived antileukoproteinase (SKALP), an elastase inhibitor from human keratinocytes. Purification and biochemical properties". Biochim. Biophys. Acta. 1096 (2): 148–54. PMID 2001428.CS1 maint: Multiple names: authors list (link)
• Sallenave JM, Ryle AP (1991). "Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor". Biol. Chem. Hoppe-Seyler. 372 (1): 13–21. PMID 2039600.
• Wiedow O, Schröder JM, Gregory H; et al. (1990). "Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence". J. Biol. Chem. 265 (25): 14791–5. PMID 2394696.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Molhuizen HO, Alkemade HA, Zeeuwen PL; et al. (1993). "SKALP/elafin: an elastase inhibitor from cultured human keratinocytes. Purification, cDNA sequence, and evidence for transglutaminase cross-linking". J. Biol. Chem. 268 (16): 12028–32. PMID 7685029.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang M, Zou Z, Maass N, Sager R (1995). "Differential expression of elafin in human normal mammary epithelial cells and carcinomas is regulated at the transcriptional level". Cancer Res. 55 (12): 2537–41. PMID 7780965.CS1 maint: Multiple names: authors list (link)
• Molhuizen HO, Zeeuwen PL, Olde Weghuis D; et al. (1994). "Assignment of the human gene encoding the epidermal serine proteinase inhibitor SKALP (PI3) to chromosome region 20q12-->q13". Cytogenet. Cell Genet. 66 (2): 129–31. PMID 8287685.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sallenave JM, Silva A (1993). "Characterization and gene sequence of the precursor of elafin, an elastase-specific inhibitor in bronchial secretions". Am. J. Respir. Cell Mol. Biol. 8 (4): 439–45. PMID 8476637.
• Tsunemi M, Matsuura Y, Sakakibara S, Katsube Y (1996). "Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution". Biochemistry. 35 (36): 11570–6. doi:10.1021/bi960900l. PMID 8794736.CS1 maint: Multiple names: authors list (link)
• Pfundt R, van Ruissen F, van Vlijmen-Willems IM; et al. (1996). "Constitutive and inducible expression of SKALP/elafin provides anti-elastase defense in human epithelia". J. Clin. Invest. 98 (6): 1389–99. PMID 8823304.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Steinert PM, Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope". J. Biol. Chem. 272 (3): 2021–30. PMID 8999895.
• Francart C, Dauchez M, Alix AJ, Lippens G (1997). "Solution structure of R-elafin, a specific inhibitor of elastase". J. Mol. Biol. 268 (3): 666–77. doi:10.1006/jmbi.1997.0983. PMID 9171290.CS1 maint: Multiple names: authors list (link)
• Kuijpers AL, Pfundt R, Zeeuwen PL; et al. (1998). "SKALP/elafin gene polymorphisms are not associated with pustular forms of psoriasis". Clin. Genet. 54 (1): 96–101. PMID 9727750.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mihaila A, Tremblay GM (2001). "Human alveolar macrophages express elafin and secretory leukocyte protease inhibitor". Z. Naturforsch., C, J. Biosci. 56 (3–4): 291–7. PMID 11371023.
• Simpson AJ, Wallace WA, Marsden ME; et al. (2001). "Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection". J. Immunol. 167 (3): 1778–86. PMID 11466403.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sumi Y, Inoue N, Azumi H; et al. (2002). "Expression of tissue transglutaminase and elafin in human coronary artery: implication for plaque instability". Atherosclerosis. 160 (1): 31–9. PMID 11755920.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)