Phenprobamate

Phenprobamate

Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	M03BA01 (WHO)
Pharmacokinetic data
Elimination half-life	5 - 8 hours
Identifiers
IUPAC name 3-Phenylpropylcarbamate
CAS Number	673-31-4 N
PubChem CID	4770
ChemSpider	4606 Y
UNII	UJZ473TPS0
KEGG	D01824 Y
ChEMBL	ChEMBL1079576 Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C10H13NO2
Molar mass	179.22
3D model (JSmol)	Interactive image
SMILES O=C(OCCCc1ccccc1)N
InChI InChI=1S/C10H13NO2/c11-10(12)13-8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H2,11,12) Y Key:CAMYKONBWHRPDD-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

WikiDoc Resources for Phenprobamate
Articles
Most recent articles on Phenprobamate Most cited articles on Phenprobamate Review articles on Phenprobamate Articles on Phenprobamate in N Eng J Med, Lancet, BMJ
Media
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Evidence Based Medicine
Cochrane Collaboration on Phenprobamate Bandolier on Phenprobamate TRIP on Phenprobamate
Clinical Trials
Ongoing Trials on Phenprobamate at Clinical Trials.gov Trial results on Phenprobamate Clinical Trials on Phenprobamate at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Phenprobamate NICE Guidance on Phenprobamate NHS PRODIGY Guidance FDA on Phenprobamate CDC on Phenprobamate
Books
Books on Phenprobamate
News
Phenprobamate in the news Be alerted to news on Phenprobamate News trends on Phenprobamate
Commentary
Blogs on Phenprobamate
Definitions
Definitions of Phenprobamate
Patient Resources / Community
Patient resources on Phenprobamate Discussion groups on Phenprobamate Patient Handouts on Phenprobamate Directions to Hospitals Treating Phenprobamate Risk calculators and risk factors for Phenprobamate
Healthcare Provider Resources
Symptoms of Phenprobamate Causes & Risk Factors for Phenprobamate Diagnostic studies for Phenprobamate Treatment of Phenprobamate
Continuing Medical Education (CME)
CME Programs on Phenprobamate
International
Phenprobamate en Espanol Phenprobamate en Francais
Business
Phenprobamate in the Marketplace Patents on Phenprobamate
Experimental / Informatics
List of terms related to Phenprobamate

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Phenprobamate (Gamaquil, Isotonil) is a centrally acting skeletal muscle relaxant, with additional sedative and anticonvulsant effects. Overdose is similar to barbiturate. Its mechanism of action is probably similar to meprobamate. Phenprobamate was previously used in humans as an anxiolytic, and is still sometimes used in general anaesthesia and for treating muscle cramps and spasticity. Phenprobamate is still used in some european countries, but it has generally been replaced by newer drugs. Phenprobamate is metabolised by oxidative degradation of the amide group and ortho-hydroxylation of the benzene ring, and is eliminated in urine by the kidneys.

Dose: 400 - 800 mg, up to 3 times a day.

References

• The Comparative Toxicogenomics Database: Phenprobamate

• BIAM: Phenprobamate (French).

• Chembank: Phenprobamate
• Nephrology Dialysis Transplantation Volume 17, Number 5, Pp. 941. Letters: Haemoperfusion may be useful in phenprobamate and polypharmacy intoxication of paediatric patients.