Pilomatricoma

	Pilomatricoma;
File:Pilomatrixoma - high mag.jpg
	Micrograph of a pilomatricoma showing the characteristic "ghost" cells (anucleate squamous cells), benign viable squamous cells and multi-nucleated giant cells. H&E stain.
ICD-10	D23
DiseasesDB	32128
eMedicine	article/1058965

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

Overview

Pilomatricoma, also known as a calcifying epithelioma of Malherbe,^[1] Malherbe calcifying epithelioma, and Pilomatrixoma, is a benign skin tumor derived from the hair matrix.^[2]^:670^[3]

Histologic features

Pilomatricomas consist of anucleate squamous cells (called "ghost cells"), benign viable squamous cells and multi-nucleated giant cells. The presence of calcifications is common.

Pathogenesis

Pilomatricoma is associated with high levels of beta-catenin caused by either a mutation in the APC gene or beta-catenin gene. These high levels of beta-catenin can aid cell proliferation, inhibit cell death, and ultimately lead to cancer.^[4]

Diagnosis

Physical Examination

Skin

Face

Pilomatricoma. With permission from Dermatology Atlas.^[5]
Pilomatricoma. With permission from Dermatology Atlas.^[5]
Pilomatricoma. With permission from Dermatology Atlas.^[5]

Perforanting Pilomatricoma

Face

Perforanting pilomatricoma. With permission from Dermatology Atlas.^[5]
Perforanting pilomatricoma. With permission from Dermatology Atlas.^[5]
Perforanting pilomatricoma. With permission from Dermatology Atlas.^[5]
Perforanting pilomatricoma. With permission from Dermatology Atlas.^[5]

References

↑ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
↑ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
↑ Levy J, Ilsar M, Deckel Y, Maly A, Anteby I, Pe'er J (2008). "Eyelid pilomatrixoma: a description of 16 cases and a review of the literature". Surv Ophthalmol. 53 (5): 526–35. doi:10.1016/j.survophthal.2008.06.007. PMID 18929763.
↑ Hassanein AM, Glanz SM, Kessler HP, Eskin TA, Liu C (2003). "beta-Catenin is expressed aberrantly in tumors expressing shadow cells. Pilomatricoma, craniopharyngioma, and calcifying odontogenic cyst". Am J Clin Pathol (5):732-6. PMID 14608900.
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 "Dermatology Atlas".

[Bolognia-1] Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.

[Andrews-2] James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.

[pmid18929763-3] Levy J, Ilsar M, Deckel Y, Maly A, Anteby I, Pe'er J (2008). "Eyelid pilomatrixoma: a description of 16 cases and a review of the literature". Surv Ophthalmol. 53 (5): 526–35. doi:10.1016/j.survophthal.2008.06.007. PMID 18929763.

[4] Hassanein AM, Glanz SM, Kessler HP, Eskin TA, Liu C (2003). "beta-Catenin is expressed aberrantly in tumors expressing shadow cells. Pilomatricoma, craniopharyngioma, and calcifying odontogenic cyst". Am J Clin Pathol (5):732-6. PMID 14608900.

[Dermatology_Atlas-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 "Dermatology Atlas".

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[5]

v t e Tumors of skin appendages (C43-C44/D22-D23, 172-173/216)
Glands/ Adnexal and skin appendage	Template:Navbox subgroup
Hair	Pilomatrixoma · Trichoepithelioma
see also non-congenital, congenital

Pilomatricoma

Overview

Histologic features

Pathogenesis

Diagnosis

Physical Examination

Skin

Face

Perforanting Pilomatricoma

Face

See also

References

Navigation menu

File:Pilomatrixoma - high mag.jpg
Pilomatricoma
Micrograph of a pilomatricoma showing the characteristic "ghost" cells (anucleate squamous cells), benign viable squamous cells and multi-nucleated giant cells. H&E stain.
ICD-10	D23
DiseasesDB	32128
eMedicine	article/1058965