Platensimycin
| Template:Chembox header| Platensimycin | |
|---|---|
| |
| Chemical name | 3-[[3-[(1R,3R,4R,5aR,9R,9aS) -1,4,5,8,9,9a-hexahydro-3,9-dimethyl -8-oxo-3H-1,4:3,5a-dimethano -2-benzoxepin-9-yl]-1-oxopropyl]amino] -2,4-dihydroxy-benzoic acid |
| Molecular formula | C24H27NO7 |
| Molar mass | 441.18 g/mol |
|
WikiDoc Resources for Platensimycin |
|
Articles |
|---|
|
Most recent articles on Platensimycin Most cited articles on Platensimycin |
|
Media |
|
Powerpoint slides on Platensimycin |
|
Evidence Based Medicine |
|
Clinical Trials |
|
Ongoing Trials on Platensimycin at Clinical Trials.gov Trial results on Platensimycin Clinical Trials on Platensimycin at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on Platensimycin NICE Guidance on Platensimycin
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on Platensimycin Discussion groups on Platensimycin Patient Handouts on Platensimycin Directions to Hospitals Treating Platensimycin Risk calculators and risk factors for Platensimycin
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for Platensimycin |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Platensimycin is a member of a previously unknown class of antibiotics, which acts by blocking enzymes involved in the of the condensation steps in fatty acid biosynthesis,[1] which bacteria need to biosynthesise cell membranes (β-ketoacyl-(acyl-carrier-protein (ACP)) synthase I/II (FabF/FabB). Other enzymes in this pathway have similarly been proven antibiotic targets for example FabI, the enoyl-ACP (acyl carrier protein) reductase, that is inhibited by isoniazid and related compounds and the antiseptic agent triclosan.[2] It is an experimental new drug in preclinical trials in an effort to combat MRSA in a mouse model.[3] The newly discovered natural product inhibitor was first isolated from a strain of Streptomyces platensis by the Merck group.[3]
Recently, a first total synthesis of racemic platensimycin has been published.[4] Its structure consists of a 3-amino-2,4-dihydroxybenzoic acid polar part linked through an amine bond to a lipophilic pentacyclicketolide.[4]
References
- ↑ Dieter Häbich, Franz von Nussbaum, ChemMedChem 2006, 1, 951–954. Platensimycin, a new antibiotic and "superbug challenger" from nature. PMID 16952137
- ↑ H T. Wright, and K.A Reynolds (2007) Antibacterial targets in fatty acid biosynthesis. Current Opinion in Microbiology doi:10.1016/j.mib.2007.07.001
- ↑ 3.0 3.1 Jun Wang et al, Platensimycin is a selective FabF inhibitor with potent antibiotic properties, Nature 441, 358-361 (18 May 2006) PMID 16710421
- ↑ 4.0 4.1 K. C. Nicolaou, A. Li, D. J. Edmonds, Angew. Chem. 2006, 118, 7244 – 7248; Angew. Chem. Int. Ed. 2006, 45, 7086 – 7090. PMID 17013803
External links
- BBC News
- Science news stories on Platensimycin
- Abstract in Nature: Platensimycin is a selective FabF inhibitor with potent antibiotic properties