Polycythemia risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2]
Overview
There are no established risk factors for developing polycythemia vera except for the genetic abnormality JAK2V617F.
Risk Factors
- One of the most common and most dangerous complications of polycythemia vera is thrombus formation. The risk factors are as follows:[1][2][3][4]
- Women- usually younger at the time of diagnosis, have a higher risk of arterio-venous thrombosis.
- Mutation- the higher burden of JAK2V617F allele
- Inflammatory markers- Pentraxins play an important role: increased hs-CRP and a lower PTX3 have a higher risk of thrombosis.
- Presence of microparticles- responsible for decreased thrombin inhibition, increased CD41, and an increased chance of splenomegaly.
- Neutrophil Extracellular Trap formations- NETosis and apoptosis.
References
- ↑ Barbui, Tiziano; Carobbio, Alessandra; Rumi, Elisa; Finazzi, Guido; Gisslinger, Heinz; Rodeghiero, Francesco; Randi, Maria Luigia; Rambaldi, Alessandro; Gisslinger, Bettina; Pieri, Lisa; Bertozzi, Irene; Casetti, Ilaria; Pardanani, Animesh; Passamonti, Francesco; Vannucchi, Alessandro M.; Tefferi, Ayalew (2014). "In contemporary patients with polycythemia vera, rates of thrombosis and risk factors delineate a new clinical epidemiology". Blood. 124 (19): 3021–3023. doi:10.1182/blood-2014-07-591610. ISSN 0006-4971.
- ↑ . doi:10.36648/1791-809X.14.6.763. Missing or empty
|title=(help) - ↑ Barbui T, Finazzi G (1997). "Risk factors and prevention of vascular complications in polycythemia vera". Semin Thromb Hemost. 23 (5): 455–61. doi:10.1055/s-2007-996122. PMID 9387204.
- ↑ Abdulkarim K, Samuelsson J, Johansson P, Andréasson B (2017). "Risk factors for vascular complications and treatment patterns at diagnosis of 2389 PV and ET patients: Real-world data from the Swedish MPN Registry". Eur J Haematol. 98 (6): 577–583. doi:10.1111/ejh.12873. PMID 28251679.