Post-thrombotic syndrome future or investigational therapies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Future or Investigational Therapies
The field of PTS still holds many unanswered questions that are important targets for more research. Those include
- fully defining the pathophysiology of PTS, including the role of inflammation and residual thrombus after completion of an appropriate duration of anticoagulant therapy
- developing a PTS risk prediction model
- role of thrombolysis ("clot-busting" drugs) in PTS prevention
- defining the true efficacy of elastic compression stockings for PTS prevention (and if effective, elucidating the minimum compression strength necessary and the optimal timing and duration of compression therapy)
- whether PTS prevention methods are necessary for patients with asymptomatic or distal DVT
- additional treatment options for PTS with demonstrated safety and efficacy (compression and pharmacologic therapies)