Pre-eclampsia natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Zand, M.D.[2] Ogheneochuko Ajari, MB.BS, MS [3]
Overview
Preeclampsic patients are usually asymptomatic and may deteriorate rapidly without any specific signs and symptoms. Early clinical feature after 20 weeks of gestation include blood pressure ≥ 140/90 mmHg, proteinuria, evidence of maternal organ involvement. Common complications of preeclampsia include: intrauterin growth retardation (IUGR), uteroplacental insufficiency, fetal asphyxia or fetal death, maternal seizures, and maternal death. Long term complication of preeclampsia include: chronic hypertension, diabetes mellitus, ischemic heart disease, cerebrovascular disease, kidney disease, thromboembolism, hypothyroidism, and impaired memory. Prognosis is generally good after delivery and controlling maternal hypertension. The five-year mortality rate of the patients with preeclampsia is approximately 0.4%.
Natural History, Complications and Prognosis
- Preeclampsic patients are usually asymptomatic and may deteriorate rapidly without any specific signs and symptoms. [1]
- Early clinical feature after 20 weeks of gestation include blood pressure ≥ 140/90 mmHg, proteinuria, evidence of maternal organ involvement.
- Common complications of preeclampsia include:
- Long term complication of preeclampsia include:[2]
- Prognosis is generally good after delivery with controlling maternal hypertension. The 5 year mortality rate of the patients with preeclampsia is approximately 0.4%.[3]
References
- ↑ Brown, Mark A.; Magee, Laura A.; Kenny, Louise C.; Karumanchi, S. Ananth; McCarthy, Fergus P.; Saito, Shigeru; Hall, David R.; Warren, Charlotte E.; Adoyi, Gloria; Ishaku, Salisu (2018). "Hypertensive Disorders of Pregnancy". Hypertension. 72 (1): 24–43. doi:10.1161/HYPERTENSIONAHA.117.10803. ISSN 0194-911X.
- ↑ Williams, David (2011). "Long-Term Complications of Preeclampsia". Seminars in Nephrology. 31 (1): 111–122. doi:10.1016/j.semnephrol.2010.10.010. ISSN 0270-9295.
- ↑ Sibai, Baha M (2002). "The Magpie Trial". The Lancet. 360 (9342): 1329. doi:10.1016/S0140-6736(02)11321-3. ISSN 0140-6736.