Primary biliary cirrhosis history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anmol Pitliya, M.B.B.S. M.D.[2]
Overview
The majority of patients with early primary biliary cirrhosis are asymptomatic.The hallmark of primary biliary cirrhosis is pruritis, worse at night. The most common symptoms of primary biliary cirrhosis include fatigue, pruritis, and jaundice.
History and Symptoms
- The majority of patients with early primary biliary cirrhosis are asymptomatic.[1]
- The hallmark of primary biliary cirrhosis is pruritis, worse at night. The most common symptoms of primary biliary cirrhosis include fatigue, pruritis, and jaundice.
History
Patients with primary biliary cirrhosis may have a positive history of:[2][3][4]
- Pruritis, worse at night
- Fatigue
- Daytime somnolence[5]
- Steatorrhea
- Fat soulble vitamin deficiency
Common Symptoms
Common symptoms of primary biliary cirrhosis include:[2]
Less Common Symptoms
Less common symptoms of primary biliary cirrhosis include:[7]
References
- ↑ Prince M, Chetwynd A, Newman W, Metcalf JV, James OF (2002). "Survival and symptom progression in a geographically based cohort of patients with primary biliary cirrhosis: follow-up for up to 28 years". Gastroenterology. 123 (4): 1044–51. PMID 12360466.
- ↑ 2.0 2.1 Witt-Sullivan H, Heathcote J, Cauch K, Blendis L, Ghent C, Katz A; et al. (1990). "The demography of primary biliary cirrhosis in Ontario, Canada". Hepatology. 12 (1): 98–105. PMID 2197212.
- ↑ Talwalkar JA, Lindor KD (2003). "Primary biliary cirrhosis". Lancet. 362 (9377): 53–61. doi:10.1016/S0140-6736(03)13808-1. PMID 12853201.
- ↑ Phillips JR, Angulo P, Petterson T, Lindor KD (2001). "Fat-soluble vitamin levels in patients with primary biliary cirrhosis". Am J Gastroenterol. 96 (9): 2745–50. doi:10.1111/j.1572-0241.2001.04134.x. PMID 11569705.
- ↑ Newton JL, Gibson GJ, Tomlinson M, Wilton K, Jones D (2006). "Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence". Hepatology. 44 (1): 91–8. doi:10.1002/hep.21230. PMID 16800007.
- ↑ Laurin JM, DeSotel CK, Jorgensen RA, Dickson ER, Lindor KD (1994). "The natural history of abdominal pain associated with primary biliary cirrhosis". Am J Gastroenterol. 89 (10): 1840–3. PMID 7942679.
- ↑ Kumagi T, Heathcote EJ (2008). "Primary biliary cirrhosis". Orphanet J Rare Dis. 3: 1. doi:10.1186/1750-1172-3-1. PMC 2266722. PMID 18215315.