Product inhibition
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Product inhibition is a type of enzyme inhibition where the product of a enzyme reaction binds to the enzyme and inhibits its activity.[1]
This can be important in the regulation of metabolism as a form of negative feedback controlling metabolic pathways.[2] Product inhibition is also an important topic in biotechnology as overcoming this effect can increase the yield of a product such as an antibiotic.[3]
References
- ↑ Walter C, Frieden E. (1963). "The prevalence and significance of the product inhibition of enzymes". Adv. Enzymol. Relat. Areas Mol. Biol. 25: 167–274. PMID 14149677.
- ↑ Hutson NJ, Kerbey AL, Randle PJ, Sugden PH (1979). "Regulation of pyruvate dehydrogenase by insulin action". Prog. Clin. Biol. Res. 31: 707–19. PMID 231784.
- ↑ Schügerl K, Hubbuch J (2005). "Integrated bioprocesses". Curr. Opin. Microbiol. 8 (3): 294–300. PMID 15939352.
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