This gene is enriched in the photoreceptors of the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene.[3]
Interactions
Protein unc-119 homolog has been shown to interact with:
↑Higashide T, Murakami A, McLaren MJ, Inana G (Mar 1996). "Cloning of the cDNA for a novel photoreceptor protein". J Biol Chem. 271 (3): 1797–804. doi:10.1074/jbc.271.3.1797. PMID8576185.
↑Higashide T, McLaren MJ, Inana G (Apr 1998). "Localization of HRG4, a photoreceptor protein homologous to Unc-119, in ribbon synapse". Invest Ophthalmol Vis Sci. 39 (5): 690–8. PMID9538874.
↑Kobayashi A, Kubota S, Mori N, McLaren MJ, Inana G (Jan 2003). "Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain". FEBS Lett. 534 (1–3): 26–32. doi:10.1016/S0014-5793(02)03766-3. PMID12527357.
↑Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID16169070.
↑Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA (Jun 2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins". J. Biol. Chem. 276 (25): 22826–37. doi:10.1074/jbc.M102359200. PMID11303027.
↑ 8.08.1Cen O, Gorska MM, Stafford SJ, Sur S, Alam R (Mar 2003). "Identification of UNC119 as a novel activator of SRC-type tyrosine kinases". J. Biol. Chem. 278 (10): 8837–45. doi:10.1074/jbc.M208261200. PMID12496276.
Swanson DA, Chang JT, Campochiaro PA, et al. (1998). "Mammalian orthologs of C. elegans unc-119 highly expressed in photoreceptors". Invest. Ophthalmol. Vis. Sci. 39 (11): 2085–94. PMID9761287.
Higashide T, Inana G (1999). "Characterization of the gene for HRG4 (UNC119), a novel photoreceptor synaptic protein homologous to unc-119". Genomics. 57 (3): 446–50. doi:10.1006/geno.1999.5791. PMID10329014.
Van Valkenburgh H, Shern JF, Sharer JD, et al. (2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins". J. Biol. Chem. 276 (25): 22826–37. doi:10.1074/jbc.M102359200. PMID11303027.
Cen O, Gorska MM, Stafford SJ, et al. (2003). "Identification of UNC119 as a novel activator of SRC-type tyrosine kinases". J. Biol. Chem. 278 (10): 8837–45. doi:10.1074/jbc.M208261200. PMID12496276.
Kobayashi A, Kubota S, Mori N, et al. (2004). "Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain". FEBS Lett. 534 (1–3): 26–32. doi:10.1016/S0014-5793(02)03766-3. PMID12527357.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.
Vepachedu R, Gorska MM, Singhania N, et al. (2007). "Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway". J. Immunol. 179 (1): 682–90. doi:10.4049/jimmunol.179.1.682. PMID17579091.
