Pseudomyxoma peritonei surgery
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Nima Nasiri, M.D.[2]Parminder Dhingra, M.D. [3]
Overview
Pseudomyxoma peritonei is a rare clinical syndrome characterized by the accumulation of ascites and mucins in the peritoneum, mainly arising from the appendix. The mainstay of therapy in patients with pseudomyxoma peritonei is cytoreductive surgery combined with intraperitoneal chemotherapeutic infusion.
Surgery
- Surgery is the mainstay of treatment for pseudomyxoma peritonei. The traditional approach was repeated surgical debulking, feasibility of surgery depends on the stage of pseudomyxoma peritonei at diagnosis.[1]
- A more aggressive approach is called cytoreductive surgery (CRS), in combination with hyperthermic intraperitoneal chemotherapy (HIPEC) which has following advantage:
- Targeting of the microscopic disease
- Minimal systemic exposure and less toxicity
- Improved chemotherapeutic drug penetration by warming to 42 degree centigerade and direct peritoneal infusion.[2][3]
References
- ↑ Qu ZB, Liu LX (October 2006). "Management of pseudomyxoma peritonei". World J. Gastroenterol. 12 (38): 6124–7. PMC 4088104. PMID 17036382.
- ↑ Vaira M, Cioppa T, DE Marco G, Bing C, D'Amico S, D'Alessandro M, Fiorentini G, DE Simone M (2009). "Management of pseudomyxoma peritonei by cytoreduction+HIPEC (hyperthermic intraperitoneal chemotherapy): results analysis of a twelve-year experience". In Vivo. 23 (4): 639–44. PMID 19567401.
- ↑ Kitai T, Kawashima M, Yamanaka K, Ichijima K, Fujii H, Mashima S, Shimahara Y (September 2011). "Cytoreductive surgery with intraperitoneal chemotherapy to treat pseudomyxoma peritonei at nonspecialized hospitals". Surg. Today. 41 (9): 1219–23. doi:10.1007/s00595-010-4495-6. PMID 21874418.