Purpura pathophysiology
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Purpura Microchapters |
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Diagnosis |
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Purpura pathophysiology On the Web |
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Risk calculators and risk factors for Purpura pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Pathophysiology
Purpura is a common and unspecific symptom, however the underlying mechanism commonly involves one of the following;
- Platelet disorders
- Primary thrombocytopenic purpura
- Secondary thrombocytopenic purpura
- Vascular disorders
- Microvascular injury, as seen in senile (old age) purpura, when blood vessels are more easily damaged
- Hypertensive states
- Deficient vascular support
- Vasculitis, as in the case of Henoch-Schönlein purpura
- Coagulation disorders
There are also cases of psychogenic purpura described in the medical literature,[1] some claimed to be due to "autoerythrocyte sensitization". Other studies[2] suggest, that local (cutaneous) activity of tPA can be increased in psychogenic purpura, leading to substantial amounts of localized plasmin activity, rapid degradation of fibrin clots, and resultant bleeding.
References
- ↑ Anderson JE, DeGoff W, McNamara M (1999). "Autoerythrocyte sensitization (psychogenic purpura): a case report and review of the literature". Pediatric emergency care. 15 (1): 47–8. PMID 10069314.
- ↑ Lotti T, Benci M, Sarti MG, Teofoli P, Senesi C, Bonan P; et al. (1993). "Psychogenic purpura with abnormallt cutaney increased tPA dependeny". 32 (7): 521–3. PMID 8340191. Unknown parameter
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