Quinine Sulfate contraindications

Quinine Sulfate
QUALAQUIN® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Overdosage
Dosage and Administration
How Supplied
Labels and Packages

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]

Contraindications

QUALAQUIN is contraindicated in patients with the following:

• Prolonged QT interval. One case of a fatal ventricular arrhythmia was reported in an elderly patient with a prolonged QT interval at baseline, who received quinine sulfate intravenously for P. falciparum malaria [see Warnings and Precautions].
• Glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• Hemolysis can occur in patients with G6PD deficiency receiving quinine.
• Known hypersensitivity reactions to quinine.
  • These include, but are not limited to, the following [see Warnings and Precautions}
  • Thrombocytopenia
  • Idiopathic thrombocytopenia purpura (ITP) and Thrombotic thrombocytopenic purpura (TTP)
  • Hemolytic uremic syndrome (HUS)
  • Blackwater fever (acute intravascular hemolysis, hemoglobinuria, and hemoglobinemia)

• Known hypersensitivity to mefloquine or quinidine: cross-sensitivity to quinine has been documented [see Warnings and Precautions ].
  • Myasthenia gravis. Quinine has neuromuscular blocking activity, and may exacerbate muscle weakness.
  • Optic neuritis. Quinine may exacerbate active optic neuritis [see Adverse Reactions].

References

Adapted from the FDA Package Insert.