Ras-related protein Rab-7b is a protein that in humans is encoded by the RAB7B gene.[1]
Function
Rab7 is a small GTPase that plays a role in the transport and degradation of proteins in endosomes and lysosomes in mammalian cells. Rab7b, is localized to lysosome-associated compartments and is selectively expressed in monocytic cells.[2] By promoting the degradation of toll-like receptor 4, RAB7B can negatively regulate the inflammatory activation of macrophages.[2]
References
↑Yang M, Chen T, Han C, Li N, Wan T, Cao X (June 2004). "Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells". Biochem. Biophys. Res. Commun. 318 (3): 792–9. doi:10.1016/j.bbrc.2004.04.115. PMID15144907.
↑ 2.02.1Wang Y, Chen T, Han C, He D, Liu H, An H, Cai Z, Cao X (August 2007). "Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4". Blood. 110 (3): 962–71. doi:10.1182/blood-2007-01-066027. PMID17395780.
Further reading
Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID8889548.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
