GTP-binding protein Rhes is a protein that in humans is encoded by the RASD2gene.[1][2][3][4]
This gene encodes a Ras-related protein that is produced largely in the striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades.[4]
References
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↑Vargiu P, De Abajo R, Garcia-Ranea JA, Valencia A, Santisteban P, Crespo P, Bernal J (Jan 2004). "The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors". Oncogene. 23 (2): 559–68. doi:10.1038/sj.onc.1207161. PMID14724584.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID15761153.
Taylor JP, Jackson DA, Morgan NG, Chan SL (2006). "Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process". Biochem. Biophys. Res. Commun. 349 (2): 809–15. doi:10.1016/j.bbrc.2006.08.102. PMID16945334.
Agretti P, De Marco G, Pinchera A, et al. (2007). "Ras homolog enriched in striatum inhibits the functional activity of wild type thyrotropin, follicle-stimulating hormone, luteinizing hormone receptors and activating thyrotropin receptor mutations by altering their expression in COS-7 cells". J. Endocrinol. Invest. 30 (4): 279–84. doi:10.1007/bf03346294. PMID17556863.
