RANBP2-like and GRIP domain-containing protein 5 is a protein that in humans is encoded by the RGPD5gene.[1][2][3]
RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene shares a high degree of sequence identity with RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. It is believed that this RANBP2 gene family member arose from a duplication event 3 Mb distal to RANBP2. Alternative splicing has been observed for this locus and two variants are described. Additional splicing is suggested but complete sequence for further transcripts has not been determined.[3]
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↑Cai, Y; Miao S Y; Wang L F (Oct 2001). "[Determination of the binding site of testis-specific nucleoporin BS-63 to transportin (karopherin beta 2) and the proof of their combination in vitro]". Zhongguo Yi Xue Ke Xue Yuan Xue Bao. China. 23 (5): 462–6. ISSN1000-503X. PMID12905863.
Further reading
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Cai Y, Miao SY, Wang LF (2004). "[Determination of the binding site of testis-specific nucleoporin BS-63 to transportin (karopherin beta 2) and the proof of their combination in vitro]". Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 23 (5): 462–6. PMID12905863.
Cai Y, Gao Y, Sheng Q, et al. (2002). "Characterization and potential function of a novel testis-specific nucleoporin BS-63". Mol. Reprod. Dev. 61 (1): 126–34. doi:10.1002/mrd.1139. PMID11774384.
Wang LF, Zhu HD, Miao SY, et al. (1999). "Molecular cloning and characterization of a novel testis-specific nucleoporin-related gene". Arch. Androl. 42 (2): 71–84. doi:10.1080/014850199262904. PMID10101573.
Nothwang HG, Rensing C, Kübler M, et al. (1998). "Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12". Genomics. 47 (3): 383–92. doi:10.1006/geno.1997.5119. PMID9480752.
