Receptor-interacting serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the RIPK4gene.[1][2]
The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation.[2]
↑Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (June 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID10830953.
↑Chen, L; Haider K; Ponda M; Cariappa A; Rowitch D; Pillai S (June 2001). "Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase". J. Biol. Chem. United States. 276 (24): 21737–44. doi:10.1074/jbc.M008069200. ISSN0021-9258. PMID11278382.
Further reading
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID8889548.
Bhr C, Rohwer A, Stempka L, et al. (2000). "DIK, a novel protein kinase that interacts with protein kinase Cdelta. Cloning, characterization, and gene analysis". J. Biol. Chem. 275 (46): 36350–7. doi:10.1074/jbc.M004771200. PMID10948194.
Chen L, Haider K, Ponda M, et al. (2001). "Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase". J. Biol. Chem. 276 (24): 21737–44. doi:10.1074/jbc.M008069200. PMID11278382.
Moran ST, Haider K, Ow Y, et al. (2003). "Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner". J. Biol. Chem. 278 (24): 21526–33. doi:10.1074/jbc.M301575200. PMID12676934.
Scanlan MJ, Gout I, Gordon CM, et al. (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immun. 1: 4. PMID12747765.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Adams S, Pankow S, Werner S, Munz B (2007). "Regulation of NF-kappaB activity and keratinocyte differentiation by the RIP4 protein: implications for cutaneous wound repair". J. Invest. Dermatol. 127 (3): 538–44. doi:10.1038/sj.jid.5700588. PMID17039240.
