RMST (gene)

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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RefSeq (mRNA)

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Rhabdomyosarcoma 2 associated transcript (RMST) is a long non-coding RNA. In humans, it is located on chromosome 12q21. It is expressed at higher levels in alveolar rhabdomyosarcoma than in embryonal rhabdomyosarcoma.[1] In the brain, RMST is expressed in the developing ventral midbrain where dopaminergic neurons are formed, the developing isthmus and in the dorsal midline cells of the rostral neural tube.[2] In the midbrain-hindbrain boundary region its expression is regulated by PAX2.[3]

See also

References

  1. ↑ Chan AS, Thorner PS, Squire JA, Zielenska M (May 2002). "Identification of a novel gene NCRMS on chromosome 12q21 with differential expression between rhabdomyosarcoma subtypes". Oncogene. 21 (19): 3029–37. doi:10.1038/sj.onc.1205460. PMID 12082533.
  2. ↑ Uhde CW, Vives J, Jaeger I, Li M (2010). "Rmst is a novel marker for the mouse ventral mesencephalic floor plate and the anterior dorsal midline cells". PLoS ONE. 5 (1): e8641. doi:10.1371/journal.pone.0008641. PMC 2799666. PMID 20062813.
  3. ↑ Bouchard M, Grote D, Craven SE, Sun Q, Steinlein P, Busslinger M (June 2005). "Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region". Development. 132 (11): 2633–43. doi:10.1242/dev.01833. PMID 15872005.

Further reading

  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
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