RNASEN

Ribonuclease III, nuclear
Identifiers
Symbols	RNASEN ; DROSHA; Etohi2; HSA242976; RANSE3L; RN3; RNASE3L
External IDs	Template:OMIM5 Template:MGI HomoloGene: 8293
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE RNASEN 218269 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ribonuclease III, nuclear, also known as RNASEN, is a human gene.

Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003).[supplied by OMIM]

Further reading

• Filippov V, Solovyev V, Filippova M, Gill SS (2000). "A novel type of RNase III family proteins in eukaryotes". Gene. 245 (1): 213–21. PMID 10713462.CS1 maint: Multiple names: authors list (link)
• Wu H, Xu H, Miraglia LJ, Crooke ST (2001). "Human RNase III is a 160-kDa protein involved in preribosomal RNA processing". J. Biol. Chem. 275 (47): 36957–65. doi:10.1074/jbc.M005494200. PMID 10948199.CS1 maint: Multiple names: authors list (link)
• Gunther M, Laithier M, Brison O (2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol. Cell. Biochem. 210 (1–2): 131–42. PMID 10976766.CS1 maint: Multiple names: authors list (link)
• Fortin KR, Nicholson RH, Nicholson AW (2003). "Mouse ribonuclease III. cDNA structure, expression analysis, and chromosomal location". BMC Genomics. 3 (1): 26. PMID 12191433.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee Y, Ahn C, Han J; et al. (2003). "The nuclear RNase III Drosha initiates microRNA processing". Nature. 425 (6956): 415–9. doi:10.1038/nature01957. PMID 14508493.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gregory RI, Yan KP, Amuthan G; et al. (2004). "The Microprocessor complex mediates the genesis of microRNAs". Nature. 432 (7014): 235–40. doi:10.1038/nature03120. PMID 15531877.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zeng Y, Yi R, Cullen BR (2005). "Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha". EMBO J. 24 (1): 138–48. doi:10.1038/sj.emboj.7600491. PMID 15565168.CS1 maint: Multiple names: authors list (link)
• Han J, Lee Y, Yeom KH; et al. (2005). "The Drosha-DGCR8 complex in primary microRNA processing". Genes Dev. 18 (24): 3016–27. doi:10.1101/gad.1262504. PMID 15574589.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Landthaler M, Yalcin A, Tuschl T (2005). "The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis". Curr. Biol. 14 (23): 2162–7. doi:10.1016/j.cub.2004.11.001. PMID 15589161.CS1 maint: Multiple names: authors list (link)
• Zeng Y, Cullen BR (2005). "Efficient processing of primary microRNA hairpins by Drosha requires flanking nonstructured RNA sequences". J. Biol. Chem. 280 (30): 27595–603. doi:10.1074/jbc.M504714200. PMID 15932881.
• Irvin-Wilson CV, Chaudhuri G (2006). "Alternative initiation and splicing in dicer gene expression in human breast cells". Breast Cancer Res. 7 (4): R563–9. doi:10.1186/bcr1043. PMID 15987463.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sugito N, Ishiguro H, Kuwabara Y; et al. (2007). "RNASEN regulates cell proliferation and affects survival in esophageal cancer patients". Clin. Cancer Res. 12 (24): 7322–8. doi:10.1158/1078-0432.CCR-06-0515. PMID 17121874.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim YK, Kim VN (2007). "Processing of intronic microRNAs". EMBO J. 26 (3): 775–83. doi:10.1038/sj.emboj.7601512. PMID 17255951.
• Xing L, Kieff E (2007). "Epstein-Barr virus BHRF1 micro- and stable RNAs during latency III and after induction of replication". J. Virol. 81 (18): 9967–75. doi:10.1128/JVI.02244-06. PMID 17626073.