RYK (gene)

RYK receptor-like tyrosine kinase
Identifiers
Symbols	RYK ; D3S3195; JTK5; JTK5A; RYK1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68287
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RYK 202853 s at tn.png
File:PBB GE RYK 214172 x at tn.png
File:PBB GE RYK 216976 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

RYK receptor-like tyrosine kinase, also known as RYK, is a human gene.

The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms.

Further reading

• Partanen J, Mäkelä TP, Alitalo R; et al. (1991). "Putative tyrosine kinases expressed in K-562 human leukemia cells". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 8913–7. PMID 2247464.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gough NM, Rakar S, Hovens CM, Wilks A (1995). "Localization of two mouse genes encoding the protein tyrosine kinase receptor-related protein RYK". Mamm. Genome. 6 (4): 255–6. PMID 7613029.CS1 maint: Multiple names: authors list (link)
• Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". Oncogene. 8 (12): 3403–10. PMID 8247543.CS1 maint: Multiple names: authors list (link)
• Stacker SA, Hovens CM, Vitali A; et al. (1993). "Molecular cloning and chromosomal localisation of the human homologue of a receptor related to tyrosine kinases (RYK)". Oncogene. 8 (5): 1347–56. PMID 8386829.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tamagnone L, Partanen J, Armstrong E; et al. (1993). "The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain". Oncogene. 8 (7): 2009–14. PMID 8390040.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang XC, Katso R, Butler R; et al. (1996). "H-RYK, an unusual receptor kinase: isolation and analysis of expression in ovarian cancer". Mol. Med. 2 (2): 189–203. PMID 8726462.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Katso RM, Russell RB, Ganesan TS (1999). "Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase family". Mol. Cell. Biol. 19 (9): 6427–40. PMID 10454588.CS1 maint: Multiple names: authors list (link)
• Trivier E, Ganesan TS (2002). "RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6". J. Biol. Chem. 277 (25): 23037–43. doi:10.1074/jbc.M202486200. PMID 11956217.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lu W, Yamamoto V, Ortega B, Baltimore D (2004). "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth". Cell. 119 (1): 97–108. doi:10.1016/j.cell.2004.09.019. PMID 15454084.CS1 maint: Multiple names: authors list (link)
• Watanabe A, Akita S, Tin NT; et al. (2006). "A mutation in RYK is a genetic factor for nonsyndromic cleft lip and palate". Cleft Palate Craniofac. J. 43 (3): 310–6. doi:10.1597/04-145R1.1. PMID 16681403.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Szafranski K, Schindler S, Taudien S; et al. "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMID 17672918.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)