Radiation proctitis historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Rekha, M.D., Mahshid Mir, M.D. [2]
Overview
In 1897, Walsh was the first to discover the association between X-ray (radiation) and the damaging effect on GI tract in a person working with the radiation energy. He further reported the improvement in the symptoms if exposure being shielded by the lead. In 1942, the early and late intestinal effect of radiotherapy was first described by Warren and Friedman.
Historical Perspective
Discovery
- X- Ray was first discovered by Wilhelm Roentgen, in 1895.
- In 1897, Walsh was the first to discover the association between X-ray (radiation) and the damaging effect on GI tract in a person working with the radiation energy. He further reported the improvement in the symptoms if exposure being shielded by the lead.
- In 1912, Regaud et al. described the delayed effects on the irradiation in the small intestine of the dogs.[1]
- In 1917, the first case of the radiation enteritis being reported in a patient being treated for the malignant disease.
- In 1930, factitial proctitis was discovered in group of patient who had undergone the pelvic radiations by Buie.
- The early and late intestinal effect of radiotherapy was first described by Warren and Friedman in 1942.
- In 1976, Goldstein et al. observed clinical improvement of a patient with radiation-induced proctitis who received salicylazo-sulfapyridine in combination with prednisone.[2]
- In 1977, Pajares et al. also observed a decrease of rectal bleeding after administration of prednisone.
- In 1984, Ben Bouali et al. demonstrated clinical and endoscopic improvement in 4 out of 33 patients treated with daily rectal administration of 5 mg of betamethasone in combination with diphenoxylate
- More recently, Triantafillidis et al. reported 5 patients treated for RP with enemas containing 5mg of betamethasone without any clinical improvement.
- In 1999, Kochhar et al. demonstrated that topical sucralfate produced sustained resolution of symptoms.[2]
References
- ↑ Trzcinski, Radzislaw; Mik, Michal; Dziki, Lukasz; Dziki, Adam (2018). "Radiation Proctitis". doi:10.5772/intechopen.76200.
- ↑ 2.0 2.1 Cotti, Guilherme; Seid, Victor; Araujo, Sérgio; Souza Jr., Afonso Henrique Silva e; Kiss, Desidério Roberto; Habr-Gama, Angelita (2003). "Conservative therapies for hemorrhagic radiation proctitis: a review". Revista do Hospital das Clínicas. 58 (5): 284–292. doi:10.1590/S0041-87812003000500008. ISSN 0041-8781.