Raine syndrome

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Raine syndrome (also called osteosclerotic bone dysplasia) is a rare disease in newborns characterized by craniofacial anomalies including microcephaly, exophthalmos, midface hypoplasia, cleft palate, gum hypertrophy and generalized osteosclerosis on radiography. It is usually lethal within a few hours after birth.

References

  • Kan A, Kozlowski K (1992). "New distinct lethal osteosclerotic bone dysplasia (Raine syndrome)". Am J Med Genet. 43 (5): 860–4. PMID 1642277.
  • Rejjal A (1998). "Raine syndrome". Am J Med Genet. 78 (4): 382–5. PMID 9714445.
  • Rickert C, Rieder H, Rehder H, Hülskamp G, Hörnig-Franz I, Louwen F, Paulus W (2002). "Neuropathology of Raine syndrome". Acta Neuropathol (Berl). 103 (3): 281–7. PMID 11907809.
  • Al-Gazali L, Jehier K, Nazih B, Abtin F, Haas D, Sadagahatian R (2003). "Further delineation of Raine syndrome". Clin Dysmorphol. 12 (2): 89–93. PMID 12868469.

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