Raltegravir dosage and administration
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]
Dosage And Administration
General Dosing Recommendations
ISENTRESS Film-Coated Tablets and Chewable Tablets can be administered with or without food [see Clinical Pharmacology]. Maximum dose of chewable tablets is 300 mg twice daily. ISENTRESS Chewable Tablets may be chewed or swallowed whole. ISENTRESS Film-Coated Tablets must be swallowed whole. Because the formulations are not bioequivalent, do not substitute chewable tablets for the 400 mg film-coated tablet. During coadministration of ISENTRESS 400 mg film-coated tablets with rifampin, the recommended dosage of ISENTRESS is 800 mg twice daily in adults. There are no data to guide co-administration of ISENTRESS with rifampin in patients below 18 years of age [see Drug Interactions].
Adults
For the treatment of adult patients with HIV-1 infection, the dosage of ISENTRESS is one 400 mg film-coated tablet administered orally, twice daily.
Pediatrics
For the treatment of children and adolescents with HIV-1 infection, the dosage of ISENTRESS is as follows:
12 years of age and older: One 400 mg film-coated tablet orally, twice daily 6 to less than 12 years of age: If at least 25 kg in weight: One 400 mg film-coated tablet orally, twice daily OR Chewable tablets: weight based to maximum dose 300 mg, twice daily as specified in Table 1
If less than 25 kg in weight: Chewable tablets: weight based to maximum dose 300 mg, twice daily as specified in Table 1
2 to less than 6 years of age: If at least 10 kg in weight: Chewable tablets: weight based to maximum dose 300 mg, twice daily as specified in Table 1
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Dosage Forms And Strengths
Film-coated Tablets 400 mg pink, oval-shaped, film-coated tablets with "227" on one side. Chewable Tablets 100 mg pale orange, oval-shaped, orange-banana flavored, chewable tablets scored on both sides and imprinted on one face with the Merck logo and "477" on opposite sides of the score. 25 mg pale yellow, round, orange-banana flavored, chewable tablets with the Merck logo on one side and "473" on the other side.[1]
References
Adapted from the FDA Package Insert.