Rapidly progressive glomerulonephritis historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Jogeet Singh Sekhon, M.D. [2]

Overview

In 1919 Ernst Goodpasture made case reports about glomerulnophritis and pulmonary haemorrhages. Stanton and Tait from Australia studied these case reports and then named the findings as Goodpasture syndrome in 1958. They gave the anti GBM antibodies classification and discovered RPGN in these cases. In 1960s electron microscopy and immunofluorescence helped to learn RPNG on immunological level.

Historical perspective

• Ernst Goodpasture made case reports about glomerulnophritis and pulmonary haemorrhages in 1919.
• Stanton and Tait from Australia studied these case reports and then named the findings as Goodpasture syndrome in 1958.
• They gave the anti GBM antibodies classification and discovered RPGN in these cases.
• In 1960s, electron microscopy and immunofluorescence helped to learn RPNG on immunological level.