Resiniferatoxin
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| Template:Chembox header| Resiniferatoxin | |
|---|---|
| Resiniferatoxin | |
| Systematic name | Resiniferatoxin |
| Chemical formula | C37H40O9 |
| Molecular mass | 628.71 g/mol |
| Density | 1.35 ± 0.1 g/cm³ |
| CAS number | 57444-62-9 |
| Template:Chembox header | Disclaimer and references | |
Resiniferatoxin (RTX) is a natural, high-potency ligand that activates the capsaicin receptor in a subpopulation of primary afferent sensory neurons involved in nociception (the transmission of physiological pain). RTX causes a novel ion channel in the plasma membrane to become permeable to cations, evoking a powerful analgesic effect. Research is being conducted at the National Institutes of Health to design a novel class of analgesics from the sap of resin spurge (Euphorbia resinifera), a cactus-like plant commonly found in Morocco that contains high concentrations of RTX.
See also
References
- Christopher S. J. Walpole; et al. (1996). "Similarities and Differences in the Structure-Activity Relationships of Capsaicin and Resiniferatoxin Analogues". J. Med. Chem. 39: 2939–2952.
External links
- Fiery pepper may hold key to easing pain
- Template:PubChem
- resiniferatoxin at the US National Library of Medicine Medical Subject Headings (MeSH)
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