Reticulum cell sarcoma pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
The dominant cell type is thought to be derived from histiocytes or macrophages. More recent thinking indicates that this cancer may arise from lymphocytes or immunoblasts.
Pathology
- Large, foam filled histiocytes with numerous mitoses and scant stroma are present
- Stains for reticulum are positive
- Periodic Acid Schiff (PAS) stains are negative