Ribavirin overdosage
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overdosage
There is limited experience with overdosage. Acute ingestion of up to 20 g of REBETOL capsules, INTRON A ingestion of up to 120 million units, and subcutaneous doses of INTRON A up to 10 times the recommended doses have been reported. Primary effects that have been observed are increased incidence and severity of the adverse reactions related to the therapeutic use of INTRON A and REBETOL. However, hepatic enzyme abnormalities, renal failure, hemorrhage, and myocardial infarction have been reported with administration of single subcutaneous doses of INTRON A that exceed dosing recommendations. There is no specific antidote for INTRON A or REBETOL overdose, and hemodialysis and peritoneal dialysis are not effective for treatment of overdose of these agents.[1]
References
- ↑ "REBETOL (RIBAVIRIN) CAPSULE REBETOL (RIBAVIRIN) LIQUID [MERCK SHARP & DOHME CORP.]". Retrieved 6 January 2014.
Adapted from the FDA Package Insert.