SELENBP1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Selenium-binding protein 1 is a protein that in humans is encoded by the SELENBP1 gene.

This gene product belongs to the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. It has been proposed that the effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins. The exact function of this gene is not known.

Interactions

SELENBP1 has been shown to interact with USP33.

Further reading

• Kim H, Kang HJ, You KT, et al. (2006). "Suppression of human selenium-binding protein 1 is a late event in colorectal carcinogenesis and is associated with poor survival". Proteomics. 6 (11): 3466–76. doi:10.1002/pmic.200500629. PMID 16645984.
• Huang KC, Park DC, Ng SK, et al. (2006). "Selenium binding protein 1 in ovarian cancer". Int. J. Cancer. 118 (10): 2433–40. doi:10.1002/ijc.21671. PMID 16380993.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Miyaguchi K (2005). "Localization of selenium-binding protein at the tips of rapidly extending protrusions". Histochem. Cell Biol. 121 (5): 371–6. doi:10.1007/s00418-004-0623-y. PMID 15108003.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Porat A; Sagiv Y; Elazar Z (2000). "A 56-kDa selenium-binding protein participates in intra-Golgi protein transport". J. Biol. Chem. 275 (19): 14457–65. doi:10.1074/jbc.275.19.14457. PMID 10799528.
• Lanfear J; Fleming J; Walker M; Harrison P (1993). "Different patterns of regulation of the genes encoding the closely related 56 kDa selenium- and acetaminophen-binding proteins in normal tissues and during carcinogenesis". Carcinogenesis. 14 (3): 335–40. doi:10.1093/carcin/14.3.335. PMID 8453708.
• Czar MJ, Owens-Grillo JK, Dittmar KD, et al. (1994). "Characterization of the protein-protein interactions determining the heat shock protein (hsp90.hsp70.hsp56) heterocomplex". J. Biol. Chem. 269 (15): 11155–61. PMID 8157642.
• Dawson SJ; White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Bartolone JB, Birge RB, Bulera SJ, et al. (1992). "Purification, antibody production, and partial amino acid sequence of the 58-kDa acetaminophen-binding liver proteins". Toxicol. Appl. Pharmacol. 113 (1): 19–29. doi:10.1016/0041-008X(92)90004-C. PMID 1553752.
• Veldscholte J, Berrevoets CA, Brinkmann AO, et al. (1992). "Anti-androgens and the mutated androgen receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation". Biochemistry. 31 (8): 2393–9. doi:10.1021/bi00123a026. PMID 1540595.