Neuronal-specific septin-3 is a protein that in humans is encoded by the SEPT3 gene .[1]
Function This gene belongs to the septin family of GTPases. Members of this family are required for cytokinesis . Expression is upregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of this gene has not been determined. Alternative splicing of this gene results in multiple transcript variants.[1]
References Further reading
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research . 6 (9): 791–806. doi :10.1101/gr.6.9.791 . PMID 8889548 . Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination" . Genome Research . 10 (11): 1788–95. doi :10.1101/gr.143000 . PMC 310948 PMID 11076863 . Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs" . Genome Research . 11 (3): 422–35. doi :10.1101/gr.GR1547R . PMC 311072 PMID 11230166 . Methner A, Leypoldt F, Joost P, Lewerenz J (April 2001). "Human septin 3 on chromosome 22q13.2 is upregulated by neuronal differentiation". Biochemical and Biophysical Research Communications . 283 (1): 48–56. doi :10.1006/bbrc.2001.4741 . PMID 11322766 . Xue J, Milburn PJ, Hanna BT, Graham ME, Rostas JA, Robinson PJ (August 2004). "Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein kinase-I in nerve terminals" . The Biochemical Journal . 381 (Pt 3): 753–60. doi :10.1042/BJ20040455 . PMC 1133885 PMID 15107017 . Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome" . Genome Biology . 5 (10): R84. doi :10.1186/gb-2004-5-10-r84 . PMC 545604 PMID 15461802 . Xue J, Tsang CW, Gai WP, Malladi CS, Trimble WS, Rostas JA, Robinson PJ (November 2004). "Septin 3 (G-septin) is a developmentally regulated phosphoprotein enriched in presynaptic nerve terminals". Journal of Neurochemistry . 91 (3): 579–90. doi :10.1111/j.1471-4159.2004.02755.x . PMID 15485489 . Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline" . Genome Research . 14 (10B): 2136–44. doi :10.1101/gr.2576704 . PMC 528930 PMID 15489336 . Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006" . Nucleic Acids Research . 34 (Database issue): D415–8. doi :10.1093/nar/gkj139 . PMC 1347501 PMID 16381901 .
