SFRS1

Jump to navigation Jump to search


Splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor)
File:PBB Protein SFRS1 image.jpg
PDB rendering based on 1x4a.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols SFRS1 ; ASF; MGC5228; SF2; SF2p33; SRp30a
External IDs Template:OMIM5 Template:MGI HomoloGene: 31411
RNA expression pattern
File:PBB GE SFRS1 208863 s at tn.png
File:PBB GE SFRS1 201742 x at tn.png
File:PBB GE SFRS1 211784 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor), also known as SFRS1, is a human gene.

This gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene.[1]

References

  1. ↑ "Entrez Gene: SFRS1 splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor)".

Further reading

  • Zahler AM, Lane WS, Stolk JA, Roth MB (1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes Dev. 6 (5): 837–47. PMID 1577277.
  • Mayeda A, Zahler AM, Krainer AR, Roth MB (1992). "Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1301–4. PMID 1741384.
  • Krainer AR, Mayeda A, Kozak D, Binns G (1991). "Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators". Cell. 66 (2): 383–94. PMID 1830244.
  • Ge H, Zuo P, Manley JL (1991). "Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators". Cell. 66 (2): 373–82. PMID 1855257.
  • Zuo P, Manley JL (1994). "The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5' splice sites". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3363–7. PMID 7512732.
  • Tacke R, Manley JL (1995). "The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities". EMBO J. 14 (14): 3540–51. PMID 7543047.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
  • Kohtz JD, Jamison SF, Will CL; et al. (1994). "Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors". Nature. 368 (6467): 119–24. doi:10.1038/368119a0. PMID 8139654.
  • Luo Y, Yu H, Peterlin BM (1994). "Cellular protein modulates effects of human immunodeficiency virus type 1 Rev". J. Virol. 68 (6): 3850–6. PMID 8189522.
  • Gui JF, Lane WS, Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. doi:10.1038/369678a0. PMID 8208298.
  • Zuo P, Manley JL (1993). "Functional domains of the human splicing factor ASF/SF2". EMBO J. 12 (12): 4727–37. PMID 8223481.
  • Wu JY, Maniatis T (1994). "Specific interactions between proteins implicated in splice site selection and regulated alternative splicing". Cell. 75 (6): 1061–70. PMID 8261509.
  • Bermingham JR, Arden KC, Naumova AK; et al. (1996). "Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2)". Genomics. 29 (1): 70–9. doi:10.1006/geno.1995.1216. PMID 8530103.
  • Colwill K, Pawson T, Andrews B; et al. (1996). "The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution". EMBO J. 15 (2): 265–75. PMID 8617202.
  • Tange TO, Jensen TH, Kjems J (1996). "In vitro interaction between human immunodeficiency virus type 1 Rev protein and splicing factor ASF/SF2-associated protein, p32". J. Biol. Chem. 271 (17): 10066–72. PMID 8626563.
  • Colwill K, Feng LL, Yeakley JM; et al. (1996). "SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors". J. Biol. Chem. 271 (40): 24569–75. PMID 8798720.
  • Zhang WJ, Wu JY (1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. 16 (10): 5400–8. PMID 8816452.
  • Powell DM, Amaral MC, Wu JY; et al. (1997). "HIV Rev-dependent binding of SF2/ASF to the Rev response element: possible role in Rev-mediated inhibition of HIV RNA splicing". Proc. Natl. Acad. Sci. U.S.A. 94 (3): 973–8. PMID 9023367.
  • Tronchère H, Wang J, Fu XD (1997). "A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA". Nature. 388 (6640): 397–400. doi:10.1038/41137. PMID 9237760.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.

Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=SFRS1&oldid=725282"