Small G protein signaling modulator 2 is a protein that in humans is encoded by the SGSM2gene.[1][2]
Clinical relevance
In a recent genome-wide association study, this gene has been associated with fasting glucose traits, type 2 diabetes and obesity.[3]
References
↑Yang, H; et al. (2007). "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway". Genomics. 90 (2): 249–260. doi:10.1016/j.ygeno.2007.03.013. PMID17509819.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID16169070.
Ishikawa K, Nagase T, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID9455477.
Yang H; Sasaki T; Minoshima S; Shimizu N (2007). "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway". Genomics. 90 (2): 249–60. doi:10.1016/j.ygeno.2007.03.013. PMID17509819.
Ishibashi K; Kanno E; Itoh T; Fukuda M (2009). "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity". Genes Cells. 14 (1): 41–52. doi:10.1111/j.1365-2443.2008.01251.x. PMID19077034.
