SIRT3

Sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)
Identifiers
Symbols	SIRT3 ; SIR2L3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 81827
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SIRT3 49327 at tn.png
File:PBB GE SIRT3 221562 s at tn.png
File:PBB GE SIRT3 221913 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae), also known as SIRT3, is a human gene.

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family.

Further reading

• Scher MB, Vaquero A, Reinberg D (2007). "SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress". Genes Dev. 21 (8): 920–8. doi:10.1101/gad.1527307. PMID 17437997.CS1 maint: Multiple names: authors list (link)
• Bellizzi D, Dato S, Cavalcante P; et al. (2007). "Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13". Genomics. 89 (1): 143–50. doi:10.1016/j.ygeno.2006.09.004. PMID 17059877.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bellizzi D, Rose G, Cavalcante P; et al. (2005). "A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages". Genomics. 85 (2): 258–63. doi:10.1016/j.ygeno.2004.11.003. PMID 15676284.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Onyango P, Celic I, McCaffery JM; et al. (2002). "SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13653–8. doi:10.1073/pnas.222538099. PMID 12374852.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schwer B, North BJ, Frye RA; et al. (2002). "The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase". J. Cell Biol. 158 (4): 647–57. doi:10.1083/jcb.200205057. PMID 12186850.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang YH, Chen YH, Zhang CY; et al. (2001). "Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene". Genomics. 69 (3): 355–69. doi:10.1006/geno.2000.6360. PMID 11056054.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Frye RA (2000). "Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins". Biochem. Biophys. Res. Commun. 273 (2): 793–8. doi:10.1006/bbrc.2000.3000. PMID 10873683.
• Frye RA (1999). "Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity". Biochem. Biophys. Res. Commun. 260 (1): 273–9. doi:10.1006/bbrc.1999.0897. PMID 10381378.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)