SLIT and NTRK-like protein 1 is a protein that in humans is encoded by the SLITRK1gene.[1][2][3]
Members of the SLITRK family, such as SLITRK1, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, but not SLITRK1, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003).[supplied by OMIM][3]
References
↑Aruga J, Yokota N, Mikoshiba K (Oct 2003). "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue". Gene. 315: 87–94. doi:10.1016/S0378-1119(03)00715-7. PMID14557068.
Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Res. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID11572484.
Aruga J, Mikoshiba K (2004). "Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth". Mol. Cell. Neurosci. 24 (1): 117–29. doi:10.1016/S1044-7431(03)00129-5. PMID14550773.
