SMTN

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Smoothelin is a protein that in humans is encoded by the SMTN gene.

This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in three transcript variants.

Further reading

• Luft FC (1999). "Differentiating one smooth operator from another". J. Mol. Med. 77 (2): 255–7. doi:10.1007/s001090050347. PMID 10023778.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• van Eys GJ, Völler MC, Timmer ED, et al. (1997). "Smoothelin expression characteristics: development of a smooth muscle cell in vitro system and identification of a vascular variant". Cell Struct. Funct. 22 (1): 65–72. doi:10.1247/csf.22.65. PMID 9113392.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Krämer J, Aguirre-Arteta AM, Thiel C, et al. (1999). "A novel isoform of the smooth muscle cell differentiation marker smoothelin". J. Mol. Med. 77 (2): 294–8. doi:10.1007/s001090050352. PMID 10023782.
• Johansson B, Eriksson A, Ramaekers F, Thornell L (2000). "Smoothelin in adult and developing human arteries and myocardium". Histochem. Cell Biol. 112 (4): 291–9. doi:10.1007/s004180050450. PMID 10550614.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Gsell S, Eschenhagen T, Kaspareit G, et al. (2000). "Apparent up-regulation of stimulatory G-protein alpha subunits in the pregnant human myometrium is mimicked by elevated smoothelin expression". FASEB J. 14 (1): 17–26. PMID 10627276.
• Krämer J, Quensel C, Meding J, et al. (2001). "Identification and characterization of novel smoothelin isoforms in vascular smooth muscle". J. Vasc. Res. 38 (2): 120–32. doi:10.1159/000051039. PMID 11316948.
• Rensen SS, Thijssen VL, De Vries CJ, et al. (2002). "Expression of the smoothelin gene is mediated by alternative promoters". Cardiovasc. Res. 55 (4): 850–63. doi:10.1016/S0008-6363(02)00491-1. PMID 12176134.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.