SON
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| SON DNA binding protein | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | SON ; BASS1; C21orf50; DBP-5; FLJ21099; FLJ33914; KIAA1019; NREBP; SON3 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 10551 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SON 214988 s at tn.png | |||||||||||
| File:PBB GE SON 201085 s at tn.png | |||||||||||
| File:PBB GE SON 201086 x at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
SON DNA binding protein, also known as SON, is a human gene.[1]
The protein encoded by this gene binds to a specific DNA sequence upstream of the upstream regulatory sequence of the core promoter and second enhancer of human hepatitis B virus (HBV). Through this binding, it represses HBV core promoter activity, transcription of HBV genes, and production of HBV virions. The protein shows sequence similarities with other DNA-binding structural proteins such as gallin, oncoproteins of the MYC family, and the oncoprotein MOS. It may also be involved in protecting cells from apoptosis and in pre-mRNA splicing. Several transcript variants encoding different isoforms have been described for this gene, but the full-length nature of only two of them has been determined.[1]
References
Further reading
- Mattioni T, Hume CR, Konigorski S; et al. (1992). "A cDNA clone for a novel nuclear protein with DNA binding activity". Chromosoma. 101 (10): 618–24. PMID 1424986.
- Bliskovskiĭ VV, Berdichevskiĭ FB, Tkachenko AV; et al. (1992). "[Coding part of the son gene small transcript contains four areas of complete tandem repeats]". Mol. Biol. (Mosk.). 26 (4): 793–806. PMID 1435773.
- Bliskovskiĭ VV, Kirillov AV, Zakhar'ev VM, Chumankov IM (1992). "[The human son gene: the large and small transcripts contains various 5'-terminal sequences]". Mol. Biol. (Mosk.). 26 (4): 807–12. PMID 1435774.
- Tassone F, Cheng S, Gardiner K (1993). "Analysis of chromosome 21 yeast artificial chromosome (YAC) clones". Am. J. Hum. Genet. 51 (6): 1251–64. PMID 1463009.
- Chumakov IM, Berdichevskiĭ FB, Sokolova NV; et al. (1991). "[Identification of a protein product of a novel human gene SON and the biological effect upon administering a changed form of this gene into mammalian cells]". Mol. Biol. (Mosk.). 25 (3): 731–9. PMID 1944255.
- Berdichevskiĭ FB, Chumakov IM, Kiselev LL (1988). "[Decoding of the primary structure of the son3 region in human genome: identification of a new protein with unusual structure and homology with DNA-binding proteins]". Mol. Biol. (Mosk.). 22 (3): 794–801. PMID 3054499.
- Khan IM, Fisher RA, Johnson KJ; et al. (1994). "The SON gene encodes a conserved DNA binding protein mapping to human chromosome 21". Ann. Hum. Genet. 58 (Pt 1): 25–34. PMID 8031013.
- Cheng S, Lutfalla G, Uze G; et al. (1993). "GART, SON, IFNAR, and CRF2-4 genes cluster on human chromosome 21 and mouse chromosome 16". Mamm. Genome. 4 (6): 338–42. PMID 8318737.
- Kikuno R, Nagase T, Ishikawa K; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. PMID 10470851.
- Greenhalf W, Lee J, Chaudhuri B (1999). "A selection system for human apoptosis inhibitors using yeast". Yeast. 15 (13): 1307–21. doi:10.1002/(SICI)1097-0061(19990930)15:13<1307::AID-YEA455>3.0.CO;2-3. PMID 10509013.
- Hattori M, Fujiyama A, Taylor TD; et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
- Wynn SL, Fisher RA, Pagel C; et al. (2001). "Organization and conservation of the GART/SON/DONSON locus in mouse and human genomes". Genomics. 68 (1): 57–62. doi:10.1006/geno.2000.6254. PMID 10950926.
- Sun CT, Lo WY, Wang IH; et al. (2001). "Transcription repression of human hepatitis B virus genes by negative regulatory element-binding protein/SON". J. Biol. Chem. 276 (26): 24059–67. doi:10.1074/jbc.M101330200. PMID 11306577.
- Reymond A, Friedli M, Henrichsen CN; et al. (2002). "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map". Genomics. 78 (1–2): 46–54. doi:10.1006/geno.2001.6640. PMID 11707072.
- Yi J, Kloeker S, Jensen CC; et al. (2002). "Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers". J. Biol. Chem. 277 (11): 9580–9. doi:10.1074/jbc.M106922200. PMID 11782456.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Casadei R, Strippoli P, D'Addabbo P; et al. (2004). "mRNA 5' region sequence incompleteness: a potential source of systematic errors in translation initiation codon assignment in human mRNAs". Gene. 321: 185–93. PMID 14637006.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
- Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
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