SPAG1

Sperm associated antigen 1
Identifiers
Symbols	SPAG1 ; FLJ32920; HSD-3.8; SP75; TPIS
External IDs	Template:OMIM5 Template:MGI HomoloGene: 8081
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE SPAG1 210117 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Sperm associated antigen 1, also known as SPAG1, is a human gene.

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.

Further reading

• Schuler GD, Boguski MS, Stewart EA; et al. (1996). "A gene map of the human genome". Science. 274 (5287): 540–6. PMID 8849440.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Diekman AB, Herr JC (1997). "Sperm antigens and their use in the development of an immunocontraceptive". Am. J. Reprod. Immunol. 37 (1): 111–7. PMID 9138444.
• Zhang ML, Wang LF, Miao SY, Koide SS (1993). "Isolation and sequencing of the cDNA encoding the 75-kD human sperm protein related to infertility". Chin. Med. J. 105 (12): 998–1003. PMID 1299558.CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Takaishi M, Huh N (1999). "A tetratricopeptide repeat-containing protein gene, tpis, whose expression is induced with differentiation of spermatogenic cells". Biochem. Biophys. Res. Commun. 264 (1): 81–5. doi:10.1006/bbrc.1999.1477. PMID 10527845.
• Lin W, Zhou X, Zhang M; et al. (2001). "Expression and function of the HSD-3.8 gene encoding a testis-specific protein". Mol. Hum. Reprod. 7 (9): 811–8. PMID 11517287.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ficarro S, Chertihin O, Westbrook VA; et al. (2003). "Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation". J. Biol. Chem. 278 (13): 11579–89. doi:10.1074/jbc.M202325200. PMID 12509440.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kanazawa R, Komori S, Sakata K; et al. (2004). "Isolation and characterization of a human sperm antigen gene h-Sp-1". Int. J. Androl. 26 (4): 226–35. PMID 12846798.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu N, Qiao Y, Cai C; et al. (2006). "A sperm component, HSD-3.8 (SPAG1), interacts with G-protein beta 1 subunit and activates extracellular signal-regulated kinases (ERK)". Front. Biosci. 11: 1679–89. PMID 16368546.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Neesse A, Gangeswaran R, Luettges J; et al. (2007). "Sperm-associated antigen 1 is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells". Oncogene. 26 (11): 1533–45. doi:10.1038/sj.onc.1209961. PMID 16983343.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)