SPAG9

Sperm associated antigen 9
Identifiers
Symbols	SPAG9 ; HSS; KIAA0516; PIG6; FLJ13450; FLJ14006; FLJ34602; HLC4; JLP; MGC117291; MGC14967; MGC74461; PHET
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2954
Gene ontology Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE SPAG9 206748 s at tn.png
File:PBB GE SPAG9 212470 at tn.png
File:PBB GE SPAG9 212468 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Sperm associated antigen 9, also known as SPAG9, is a human gene.

Extracellular signals are transduced into cells through mitogen-activated protein kinases. The structural organization of these kinases into specific signaling domains is facilitated by scaffolding proteins involved in closely tethering different kinases so that successive phosphorylation events can occur. The protein encoded by this gene is a scaffolding protein that brings together mitogen-activated protein kinases and their transcription factor targets for the activation of specific signaling pathways. This gene which is abundantly expressed in testicular haploid germ cells encodes a protein that is recognized by sperm-agglutinating antibodies and implicated in infertility.

Further reading

• Ichijo H (1999). "From receptors to stress-activated MAP kinases". Oncogene. 18 (45): 6087–93. doi:10.1038/sj.onc.1203129. PMID 10557099.
• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. PMID 12168954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shankar S, Mohapatra B, Suri A (1998). "Cloning of a novel human testis mRNA specifically expressed in testicular haploid germ cells, having unique palindromic sequences and encoding a leucine zipper dimerization motif". Biochem. Biophys. Res. Commun. 243 (2): 561–5. doi:10.1006/bbrc.1997.7943. PMID 9480848.CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Miyajima N; et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. PMID 9628581.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee CM, Onésime D, Reddy CD; et al. (2002). "JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14189–94. doi:10.1073/pnas.232310199. PMID 12391307.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yasuoka H, Ihn H, Medsger TA; et al. (2004). "A novel protein highly expressed in testis is overexpressed in systemic sclerosis fibroblasts and targeted by autoantibodies". J. Immunol. 171 (12): 6883–90. PMID 14662895.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bouwmeester T, Bauch A, Ruffner H; et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brill LM, Salomon AR, Ficarro SB; et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jagadish N, Rana R, Selvi R; et al. (2005). "Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein". Biochem. J. 389 (Pt 1): 73–82. doi:10.1042/BJ20041577. PMID 15693750.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jagadish N, Rana R, Mishra D; et al. (2005). "Sperm associated antigen 9 (SPAG9): a new member of c-Jun NH2 -terminal kinase (JNK) interacting protein exclusively expressed in testis". The Keio journal of medicine. 54 (2): 66–71. PMID 16077255.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guinn BA, Bland EA, Lodi U; et al. (2005). "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia". Biochem. Biophys. Res. Commun. 335 (4): 1293–304. doi:10.1016/j.bbrc.2005.08.024. PMID 16112646.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rana R, Jagadish N, Garg M; et al. (2006). "Small interference RNA-mediated knockdown of sperm associated antigen 9 having structural homology with c-Jun N-terminal kinase-interacting protein". Biochem. Biophys. Res. Commun. 340 (1): 158–64. doi:10.1016/j.bbrc.2005.11.168. PMID 16356479.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rana R, Jagadish N, Garg M; et al. (2007). "Immunogenicity study of recombinant human sperm-associated antigen 9 in bonnet macaque (Macaca radiata)". Hum. Reprod. 21 (11): 2894–900. doi:10.1093/humrep/del068. PMID 16959808.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)