SRGN

Serglycin
Identifiers
Symbols	SRGN ; PRG; FLJ12930; MGC9289; PPG; PRG1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2043
Gene ontology
RNA expression pattern
File:PBB GE SRGN 201859 at tn.png
File:PBB GE SRGN 201858 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Serglycin, also known as SRGN, is a human gene.

This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis.

Further reading

• Schick BP (2000). "Regulation of expression of megakaryocyte and platelet proteoglycans". Stem Cells. 14 Suppl 1: 220–31. PMID 11012225.
• Humphries DE, Nicodemus CF, Schiller V, Stevens RL (1992). "The human serglycin gene. Nucleotide sequence and methylation pattern in human promyelocytic leukemia HL-60 cells and T-lymphoblast Molt-4 cells". J. Biol. Chem. 267 (19): 13558–63. PMID 1377686.CS1 maint: Multiple names: authors list (link)
• Nicodemus CF, Avraham S, Austen KF; et al. (1990). "Characterization of the human gene that encodes the peptide core of secretory granule proteoglycans in promyelocytic leukemia HL-60 cells and analysis of the translated product". J. Biol. Chem. 265 (10): 5889–96. PMID 2180935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mattei MG, Périn JP, Alliel PM; et al. (1989). "Localization of human platelet proteoglycan gene to chromosome 10, band q22.1, by in situ hybridization". Hum. Genet. 82 (1): 87–8. PMID 2714783.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Avraham S, Stevens RL, Nicodemus CF; et al. (1989). "Molecular cloning of a cDNA that encodes the peptide core of a mouse mast cell secretory granule proteoglycan and comparison with the analogous rat and human cDNA". Proc. Natl. Acad. Sci. U.S.A. 86 (10): 3763–7. PMID 2726751.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stellrecht CM, Saunders GF (1989). "Nucleotide sequence of a cDNA encoding a hemopoietic proteoglycan core protein". Nucleic Acids Res. 17 (18): 7523. PMID 2798108.
• Stevens RL, Avraham S, Gartner MC; et al. (1988). "Isolation and characterization of a cDNA that encodes the peptide core of the secretory granule proteoglycan of human promyelocytic leukemia HL-60 cells". J. Biol. Chem. 263 (15): 7287–91. PMID 2835370.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Périn JP, Bonnet F, Maillet P, Jollès P (1989). "Characterization and N-terminal sequence of human platelet proteoglycan". Biochem. J. 255 (3): 1007–13. PMID 3214420.CS1 maint: Multiple names: authors list (link)
• Avraham S, Stevens RL, Gartner MC; et al. (1988). "Isolation of a cDNA that encodes the peptide core of the secretory granule proteoglycan of rat basophilic leukemia-1 cells and assessment of its homology to the human analogue". J. Biol. Chem. 263 (15): 7292–6. PMID 3366780.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Alliel PM, Périn JP, Maillet P; et al. (1988). "Complete amino acid sequence of a human platelet proteoglycan". FEBS Lett. 236 (1): 123–6. PMID 3402609.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hatton MN, Loomis RE, Levine MJ, Tabak LA (1985). "Masticatory lubrication. The role of carbohydrate in the lubricating property of a salivary glycoprotein-albumin complex". Biochem. J. 230 (3): 817–20. PMID 4062880.CS1 maint: Multiple names: authors list (link)
• Schick BP, Jacoby JA (1995). "Serglycin and betaglycan proteoglycans are expressed in the megakaryocytic cell line CHRF 288-11 and normal human megakaryocytes". J. Cell. Physiol. 165 (1): 96–106. doi:10.1002/jcp.1041650113. PMID 7559813.
• Kato S, Sekine S, Oh SW; et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. PMID 7821789.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kolset SO, Mann DM, Uhlin-Hansen L; et al. (1996). "Serglycin-binding proteins in activated macrophages and platelets". J. Leukoc. Biol. 59 (4): 545–54. PMID 8613703.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Toyama-Sorimachi N, Kitamura F, Habuchi H; et al. (1997). "Widespread expression of chondroitin sulfate-type serglycins with CD44 binding ability in hematopoietic cells". J. Biol. Chem. 272 (42): 26714–9. PMID 9334256.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Galvin JP, Spaeny-Dekking LH, Wang B; et al. (1999). "Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo". J. Immunol. 162 (9): 5345–50. PMID 10228010.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schick BP, Gradowski JF, San Antonio JD (2001). "Synthesis, secretion, and subcellular localization of serglycin proteoglycan in human endothelial cells". Blood. 97 (2): 449–58. PMID 11154222.CS1 maint: Multiple names: authors list (link)
• Omtvedt LA, Kolset SO, Thoen J; et al. (2001). "Serglycin expression in CD2+ and CD14+ cells from patients with various rheumatic diseases". Scand. J. Rheumatol. 30 (3): 164–6. PMID 11469527.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Metkar SS, Wang B, Aguilar-Santelises M; et al. (2002). "Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation". Immunity. 16 (3): 417–28. PMID 11911826.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)