STAM

Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Identifiers
Symbols	STAM ; DKFZp686J2352; STAM1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37788
Gene ontology Molecular function Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE STAM 203544 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1, also known as STAM, is a human gene.

This gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains an SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). This protein associates with JAK3 and JAK2 kinases via its ITAM region, and is phosphorylated by the JAK kinases upon cytokine stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of cytokine receptors. HGS/HRS (hepatocyte growth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein.

Further reading

• Takeshita T, Arita T, Asao H; et al. (1996). "Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM". Biochem. Biophys. Res. Commun. 225 (3): 1035–9. doi:10.1006/bbrc.1996.1290. PMID 8780729.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takeshita T, Arita T, Higuchi M; et al. (1997). "STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction". Immunity. 6 (4): 449–57. PMID 9133424.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Asao H, Sasaki Y, Arita T; et al. (1998). "Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth". J. Biol. Chem. 272 (52): 32785–91. PMID 9407053.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanaka N, Kaneko K, Asao H; et al. (1999). "Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines". J. Biol. Chem. 274 (27): 19129–35. PMID 10383417.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Endo K, Takeshita T, Kasai H; et al. (2000). "STAM2, a new member of the STAM family, binding to the Janus kinases". FEBS Lett. 477 (1–2): 55–61. PMID 10899310.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kato M, Miyazawa K, Kitamura N (2001). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". J. Biol. Chem. 275 (48): 37481–7. doi:10.1074/jbc. M007251200 . PMID 10982817.CS1 maint: Multiple names: authors list (link)
• Pandey A, Fernandez MM, Steen H; et al. (2001). "Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways". J. Biol. Chem. 275 (49): 38633–9. doi:10.1074/jbc. M007849200 . PMID 10993906.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Steen H, Kuster B, Fernandez M; et al. (2002). "Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway". J. Biol. Chem. 277 (2): 1031–9. doi:10.1074/jbc. M109992200 . PMID 11687594.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bache KG, Raiborg C, Mehlum A, Stenmark H (2003). "STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes". J. Biol. Chem. 278 (14): 12513–21. doi:10.1074/jbc. M210843200 . PMID 12551915.CS1 maint: Multiple names: authors list (link)
• Blackstone C, Roberts RG, Seeburg DP, Sheng M (2003). "Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1". Biochem. Biophys. Res. Commun. 305 (2): 345–52. PMID 12745081.CS1 maint: Multiple names: authors list (link)
• Mizuno E, Kawahata K, Kato M; et al. (2004). "STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif". Mol. Biol. Cell. 14 (9): 3675–89. doi:10.1091/mbc. E02-12-0823 . PMID 12972556.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mizuno E, Kawahata K, Okamoto A; et al. (2005). "Association with Hrs is required for the early endosomal localization, stability, and function of STAM". J. Biochem. 135 (3): 385–96. PMID 15113837.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kobayashi H, Tanaka N, Asao H; et al. (2005). "Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2". J. Biol. Chem. 280 (11): 10468–77. doi:10.1074/jbc. M409969200 . PMID 15640163.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Row PE, Clague MJ, Urbé S (2005). "Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex: a common node in signalling networks with signal-specific properties". Biochem. J. 389 (Pt 3): 629–36. doi:10.1042/BJ20050067. PMID 15828871.CS1 maint: Multiple names: authors list (link)
• Zhang Y, Wolf-Yadlin A, Ross PL; et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell Proteomics. 4 (9): 1240–50. doi:10.1074/mcp. M500089-MCP200 . PMID 15951569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)