STK35L1
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STK35L1 is a protein that in humans is encoded by the STK35 (serine/threonine kinase 35) gene.[1] It is a member of the NKF4 (New Kinase Family 4) Ser/Thr kinases (STK) family and classified in group "Other" in the human kinome. Previously, STK35L1 was named as Clik1 (CLP36 Interacting Kinase 1) based on a study that showed an association of STK35 with CLP36 after overexpression of both proteins in osteosarcoma cells.[2][3] Clik1 gene described by Vallenius et al. code for a protein of 501 amino acids. Later, Goyal et al. found that coding sequence of the STK35 gene is incomplete. The newly identified sequence of the STK35 gene codes for a protein of 534 amino acids with a N-terminal elongation of 133 amino acids. It has been designated as STK35L1.
Functions
STK35L1 is predominantly found in the nucleus and the nucleolus. Nuclear actin was identified as a novel binding partner of STK35L1.[4] However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. STK35L1 regulates the expression of CDKN2A and inhibiting G1- to S-phase transition.Depletion of STK35L1 by siRNA impaired endothelial cell migration. STK35L1 may act as a central kinase linking the cell cycle and migration of endothelial cells.
References
- ↑ "Entrez Gene: Serine/threonine kinase 35". Retrieved 2012-02-18.
- ↑ Vallenius T, Mäkelä TP (May 2002). "Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein". Journal of Cell Science. 115 (Pt 10): 2067–73. PMID 11973348.
- ↑ Goyal P, Behring A, Kumar A, Siess W (2009-09-16). "Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates". PLoS One. 4 (9): e6981. doi:10.1371/journal.pone.0006981. PMC 2737284. PMID 19756140.
- ↑ Goyal P, Behring A, Kumar A, Siess W (2011-01-20). "STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells". PLoS One. 6 (1): e16249. doi:10.1371/journal.pone.0016249. PMC 3024402. PMID 21283756.
Further reading
- Vallenius T, Mäkelä TP (May 2002). "Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein". Journal of Cell Science. 115 (Pt 10): 2067–73. PMID 11973348.
- Goyal P, Behring A, Kumar A, Siess W (2009). Randau L, ed. "Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates". PLoS One. 4 (9): e6981. doi:10.1371/journal.pone.0006981. PMC 2737284. PMID 19756140.
- Goyal P, Behring A, Kumar A, Siess W (2011). Parise G, ed. "STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells". PLoS One. 6 (1): e16249. doi:10.1371/journal.pone.0016249. PMC 3024402. PMID 21283756.
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