Syntaxin-10 (STX10) is a SNARE protein that is encoded by the STX10gene.[1] This protein is found in most vertebrates (including humans) but is noticeably absent from mice.[2][3] As with other SNARE proteins, STX10 facilitates vesicle fusion and thus is important for intracellular trafficking of proteins and other cellular components. More specifically, STX10 has been implicated in endosome to Golgi trafficking of the mannose 6-phosphate receptor[2] and glucose transporter type 4.[3]
STX10 is structurally classified as a Qc-SNARE (contributes a glutamine (Q) residue in the formation of the assembled core SNARE complex) and is functionally classified as a t-SNARE (or target-SNARE which is often located in the membranes of target compartments).[4]
Interactions
STX10 is known to interact with the t-SNAREs VTI1A and STX16[5] and with the v-SNAREs VAMP3[2] and VAMP4.[5] The SNARE complex of STX10, STX16, VTI1A, and VAMP3 are required for late endosome to Golgi trafficking of the mannose 6-phosphate receptor.[2] Early endosome to Golgi trafficking of Shiga toxin requires the SNARE complex of STX6, STX16, VTI1A, and VAMP3 or VAMP4.[6]
Thus, STX10 distinguishes early endosome to Golgi trafficking from late endosome to Golgi trafficking.[2]
References
↑ 1.01.11.2Tang BL, Low DY, Tan AE, Hong W (January 1998). "Syntaxin 10: a member of the syntaxin family localized to the trans-Golgi network". Biochemical and Biophysical Research Communications. 242 (2): 345–50. doi:10.1006/bbrc.1997.7966. PMID9446797.
↑ 5.05.1Wang Y, Tai G, Lu L, Johannes L, Hong W, Tang BL (Jul–Aug 2005). "Trans-Golgi network syntaxin 10 functions distinctly from syntaxins 6 and 16". Molecular Membrane Biology. 22 (4): 313–25. doi:10.1080/09687860500143829. PMID16154903.
