Sandbox/v50

WHO Histological Classification of Tumors of the Lung

Malignant Epithelial Tumors

• Squamous cell carcinoma

• Papillary
• Clear cell
• Small cell
• Basaloid

• Small cell carcinoma

• Combined small cell carcinoma

• Adenocarcinoma

• Adenocarcinoma, mixed subtype
• Acinar adenocarcinoma
• Papillary adenocarcinoma
• Bronchioloalveolar carcinoma

• Nonmucinous
• Mucinous
• Mixed nonmucinous and mucinous or indeterminate

• Solid adenocarcinoma with mucin production

• Fetal adenocarcinoma
• Mucinous (“colloid”) carcinoma
• Mucinous cystadenocarcinoma
• Signet ring adenocarcinoma
• Clear cell adenocarcinoma

• Large cell carcinoma

• Large cell neuroendocrine carcinoma

• Combined large cell neuroendocrine carcinoma

• Basaloid carcinoma
• Lymphoepithelioma-like carcinoma
• Clear cell carcinoma
• Large cell carcinoma with rhabdoid phenotype

• Adenosquamous carcinoma

• Sarcomatoid carcinoma

• Pleomorphic carcinoma
• Spindle cell carcinoma
• Giant cell carcinoma
• Carcinosarcoma
• Pulmonary blastoma

• Carcinoid tumor

• Typical carcinoid
• Atypical carcinoid

• Salivary gland tumors

• Mucoepidermoid carcinoma
• Adenoid cystic carcinoma
• Epithelial-myoepithelial carcinoma

• Preinvasive lesions

• Squamous carcinoma in situ
• Atypical adenomatous hyperplasia
• Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia

• Mesenchymal tumors

• Epithelioid haemangioendothelioma
• Angiosarcoma
• Pleuropulmonary blastoma
• Chondroma
• Congenial peribronchial myofibroblastic tumor
• Diffuse pulmonary lymphangiomatosis
• Inflammatory myofibroblastic tumor
• Lymphangioleiomyomatosis
• Synovial sarcoma

• Monophasic
• Biphasic

• Pulmonary artery sarcoma
• Pulmonary vein sarcoma

Benign Epithelial Tumors

• Papillomas

• Squamous cell papilloma

• Exophytic
• Inverted

• Glandular papilloma
• Mixed squamous cell and glandular papilloma

• Adenomas

• Alveolar adenoma
• Papillary adenoma
• Adenomas of the salivary gland type

• Mucous gland adenoma
• Pleomorphic adenoma
• Others

• Mucinous cystadenoma

Lymphoproliferative Tumors

• Marginal zone B-cell lymphoma of the MALT type

• Diffuse large B-cell lymphoma

• Lymphomatoid granulomatosis

• Langerhans cell histiocytosis

Miscellaneous Tumors

• Harmatoma

• Sclerosing hemangioma

• Clear cell tumor

• Germ cell tumors

• Teratoma, mature
• Immature
• Other germ cell tumors

• Intrapulmonary thymoma

• Melanoma

Metastatic Tumors

Rerefences