Sandbox: Kaposi

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Clincal Stage Histologic Features

Macular stage

  • Thin vessel wall
  • Angulated vessels throughout dermis
  • Plasma cell and hemosiderin infiltrates

Patch stage

  • Angulated lumina that dissect dermal collagen
  • Premonitory sign
  • Spindle cells surround angiomatoid vascular spaces filled with RBC

Tumor stage

  • Solid nodules
  • The presence of spindle cells and red blood cells in a slit-like lumina
  • Abscence of cellular atypia or mitotic activity

Lymphangioma-like variant

  • Thin walled, angulated vessels
  • Absence of red blood cells